Integrating Retrogenesis Theory to Alzheimer’s Disease Pathology: Insight from DTI-TBSS Investigation of the White Matter Microstructural Integrity
Microstructural abnormalities in white matter (WM) are often reported in Alzheimer’s disease (AD) and may reflect primary or secondary circuitry degeneration (i.e., due to cortical atrophy). The interpretation of diffusion tensor imaging (DTI) eigenvectors, known as multiple indices, may provide new...
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description | Microstructural abnormalities in white matter (WM) are often reported in Alzheimer’s disease (AD) and may reflect primary or secondary circuitry degeneration (i.e., due to cortical atrophy). The interpretation of diffusion tensor imaging (DTI) eigenvectors, known as multiple indices, may provide new insights into the main pathological models supporting primary or secondary patterns of WM disruption in AD, the retrogenesis, and Wallerian degeneration models, respectively. The aim of this review is to analyze the current literature on the contribution of DTI multiple indices to the understanding of AD neuropathology, taking the retrogenesis model as a reference for discussion. A systematic review using MEDLINE, EMBASE, and PUBMED was performed. Evidence suggests that AD evolves through distinct patterns of WM disruption, in which retrogenesis or, alternatively, the Wallerian degeneration may prevail. Distinct patterns of WM atrophy may be influenced by complex interactions which comprise disease status and progression, fiber localization, concurrent risk factors (i.e., vascular disease, gender), and cognitive reserve. The use of DTI multiple indices in addition to other standard multimodal methods in dementia research may help to determine the contribution of retrogenesis hypothesis to the understanding of neuropathological hallmarks that lead to AD. |
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David</contributor><creatorcontrib>Laks, Jerson ; Pantel, Johannes ; Carvalho, André Férrer ; Knöchel, Christian ; Oertel Knöchel, Viola ; Alves, Gilberto Sousa ; Engelhardt, Eliasz ; Arnold, W. David</creatorcontrib><description>Microstructural abnormalities in white matter (WM) are often reported in Alzheimer’s disease (AD) and may reflect primary or secondary circuitry degeneration (i.e., due to cortical atrophy). The interpretation of diffusion tensor imaging (DTI) eigenvectors, known as multiple indices, may provide new insights into the main pathological models supporting primary or secondary patterns of WM disruption in AD, the retrogenesis, and Wallerian degeneration models, respectively. The aim of this review is to analyze the current literature on the contribution of DTI multiple indices to the understanding of AD neuropathology, taking the retrogenesis model as a reference for discussion. A systematic review using MEDLINE, EMBASE, and PUBMED was performed. Evidence suggests that AD evolves through distinct patterns of WM disruption, in which retrogenesis or, alternatively, the Wallerian degeneration may prevail. Distinct patterns of WM atrophy may be influenced by complex interactions which comprise disease status and progression, fiber localization, concurrent risk factors (i.e., vascular disease, gender), and cognitive reserve. The use of DTI multiple indices in addition to other standard multimodal methods in dementia research may help to determine the contribution of retrogenesis hypothesis to the understanding of neuropathological hallmarks that lead to AD.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2015/291658</identifier><identifier>PMID: 25685779</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Alzheimer Disease - pathology ; Alzheimer Disease - physiopathology ; Alzheimer's disease ; Cognitive ability ; Development and progression ; Humans ; Hypotheses ; Medical imaging ; Medical research ; Medicine, Experimental ; Models, Neurological ; Neuropathology ; Pathology ; Retrogenesis ; Review ; Studies ; Theory ; White Matter - pathology ; White Matter - physiopathology</subject><ispartof>BioMed research international, 2015-01, Vol.2015 (2015), p.1-11</ispartof><rights>Copyright © 2015 Gilberto Sousa Alves et al.</rights><rights>COPYRIGHT 2015 John Wiley & Sons, Inc.</rights><rights>Copyright © 2015 Gilberto Sousa Alves et al. Gilberto Sousa Alves et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2015 Gilberto Sousa Alves et al. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c594t-5d618a71190db867220d771acebf495423e78292d92b1062b4a527b7a25892d03</citedby><cites>FETCH-LOGICAL-c594t-5d618a71190db867220d771acebf495423e78292d92b1062b4a527b7a25892d03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320890/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320890/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25685779$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Arnold, W. David</contributor><creatorcontrib>Laks, Jerson</creatorcontrib><creatorcontrib>Pantel, Johannes</creatorcontrib><creatorcontrib>Carvalho, André Férrer</creatorcontrib><creatorcontrib>Knöchel, Christian</creatorcontrib><creatorcontrib>Oertel Knöchel, Viola</creatorcontrib><creatorcontrib>Alves, Gilberto Sousa</creatorcontrib><creatorcontrib>Engelhardt, Eliasz</creatorcontrib><title>Integrating Retrogenesis Theory to Alzheimer’s Disease Pathology: Insight from DTI-TBSS Investigation of the White Matter Microstructural Integrity</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Microstructural abnormalities in white matter (WM) are often reported in Alzheimer’s disease (AD) and may reflect primary or secondary circuitry degeneration (i.e., due to cortical atrophy). The interpretation of diffusion tensor imaging (DTI) eigenvectors, known as multiple indices, may provide new insights into the main pathological models supporting primary or secondary patterns of WM disruption in AD, the retrogenesis, and Wallerian degeneration models, respectively. The aim of this review is to analyze the current literature on the contribution of DTI multiple indices to the understanding of AD neuropathology, taking the retrogenesis model as a reference for discussion. A systematic review using MEDLINE, EMBASE, and PUBMED was performed. Evidence suggests that AD evolves through distinct patterns of WM disruption, in which retrogenesis or, alternatively, the Wallerian degeneration may prevail. Distinct patterns of WM atrophy may be influenced by complex interactions which comprise disease status and progression, fiber localization, concurrent risk factors (i.e., vascular disease, gender), and cognitive reserve. The use of DTI multiple indices in addition to other standard multimodal methods in dementia research may help to determine the contribution of retrogenesis hypothesis to the understanding of neuropathological hallmarks that lead to AD.</description><subject>Alzheimer Disease - pathology</subject><subject>Alzheimer Disease - physiopathology</subject><subject>Alzheimer's disease</subject><subject>Cognitive ability</subject><subject>Development and progression</subject><subject>Humans</subject><subject>Hypotheses</subject><subject>Medical imaging</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Models, Neurological</subject><subject>Neuropathology</subject><subject>Pathology</subject><subject>Retrogenesis</subject><subject>Review</subject><subject>Studies</subject><subject>Theory</subject><subject>White Matter - pathology</subject><subject>White Matter - physiopathology</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNks1u1DAUhSMEolXpij2yxAaBBmwnjm0WlYaWn5FagegglpaT3CSuMnaxnaJhxUuw4PV4EhylDIVVvbCt609H516fLHtI8HNCGHtBMUmbJCUTd7J9mpNiUZKC3N3d83wvOwzhAqclSIlleT_bo6wUjHO5n_1Y2Qid19HYDn2E6F0HFoIJaN2D81sUHVoO33owG_C_vv8M6MQE0AHQBx17N7hu-xKtbDBdH1Hr3QadrFeL9avz81S9ghBNl7SdRa5FsQf0uTcR0JmOETw6M7V3IfqxjqPXA5q9mLh9kN1r9RDg8Po8yD69eb0-frc4ff92dbw8XdRMFnHBmpIIzQmRuKlEySnFDedE11C1hWQFzYELKmkjaUVwSatCM8orrikTqYrzg-xo1r0cqw00NdiYfKhLbzbab5XTRv37Yk2vOnelipxiISeBJ9cC3n0ZU7tqY0INw6AtuDEoUpZSJJiw26A4F4ISktDH_6EXbvQ2TSJRDGOOk-pfqtMDKGNblyzWk6haFmz6a8Emh89mahp18NDuuiNYTRFSU4TUHKFEP7o5kB37JzAJeDoDvbGN_mpupwYJgVbfgFkhCc9_A9jG2EI</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Laks, Jerson</creator><creator>Pantel, Johannes</creator><creator>Carvalho, André Férrer</creator><creator>Knöchel, Christian</creator><creator>Oertel Knöchel, Viola</creator><creator>Alves, Gilberto Sousa</creator><creator>Engelhardt, Eliasz</creator><general>Hindawi Publishing Corporation</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150101</creationdate><title>Integrating Retrogenesis Theory to Alzheimer’s Disease Pathology: Insight from DTI-TBSS Investigation of the White Matter Microstructural Integrity</title><author>Laks, Jerson ; Pantel, Johannes ; Carvalho, André Férrer ; Knöchel, Christian ; Oertel Knöchel, Viola ; Alves, Gilberto Sousa ; Engelhardt, Eliasz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c594t-5d618a71190db867220d771acebf495423e78292d92b1062b4a527b7a25892d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Alzheimer Disease - 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subjects | Alzheimer Disease - pathology Alzheimer Disease - physiopathology Alzheimer's disease Cognitive ability Development and progression Humans Hypotheses Medical imaging Medical research Medicine, Experimental Models, Neurological Neuropathology Pathology Retrogenesis Review Studies Theory White Matter - pathology White Matter - physiopathology |
title | Integrating Retrogenesis Theory to Alzheimer’s Disease Pathology: Insight from DTI-TBSS Investigation of the White Matter Microstructural Integrity |
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