MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4

A body of experimental evidence suggests that T cells mediate neuroprotection following CNS injury; however, the antigen specificity of these T cells and how they mediate neuroprotection are unknown. Here, we have provided evidence that T cell-mediated neuroprotection after CNS injury can occur inde...

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Veröffentlicht in:	The Journal of clinical investigation 2015-02, Vol.125 (2), p.699-714
Hauptverfasser:	Walsh, James T, Hendrix, Sven, Boato, Francesco, Smirnov, Igor, Zheng, Jingjing, Lukens, John R, Gadani, Sachin, Hechler, Daniel, Gölz, Greta, Rosenberger, Karen, Kammertöns, Thomas, Vogt, Johannes, Vogelaar, Christina, Siffrin, Volker, Radjavi, Ali, Fernandez-Castaneda, Anthony, Gaultier, Alban, Gold, Ralf, Kanneganti, Thirumala-Devi, Nitsch, Robert, Zipp, Frauke, Kipnis, Jonathan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axons - immunology Axons - pathology Brain Injuries - genetics Brain Injuries - immunology Brain Injuries - pathology CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - pathology Extracellular Signal-Regulated MAP Kinases - genetics Extracellular Signal-Regulated MAP Kinases - immunology Histocompatibility Antigens Class II - genetics Histocompatibility Antigens Class II - immunology Interleukin-4 - genetics Interleukin-4 - immunology MAP Kinase Signaling System - genetics MAP Kinase Signaling System - immunology Mice Mice, Knockout Myeloid Differentiation Factor 88 - genetics Myeloid Differentiation Factor 88 - immunology Neurodegenerative Diseases - genetics Neurodegenerative Diseases - immunology Neurodegenerative Diseases - pathology Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - immunology Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - immunology
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