Effect of Biofilms on Recalcitrance of Staphylococcal Joint Infection to Antibiotic Treatment

The pathogenesis of joint infections is not well understood. In particular, we do not know why these infections respond poorly to antibiotic treatment. Here we show that methicillin-resistant Staphylococcus aureus, a major cause of joint infections, forms exceptionally strong biofilmlike aggregates...

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Veröffentlicht in:	The Journal of infectious diseases 2015-02, Vol.211 (4), p.641-650
Hauptverfasser:	Dastgheyb, Sana, Parvizi, Javad, Shapiro, Irving M., Hickok, Noreen J., Otto, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Arthritis, Infectious - microbiology BACTERIA Biofilms - growth & development Colony Count, Microbial Fibrinolysin - pharmacology Humans Major and Brief Reports Methicillin-Resistant Staphylococcus aureus - drug effects Methicillin-Resistant Staphylococcus aureus - growth & development Models, Biological Staphylococcal Infections - microbiology Staphylococcus aureus Synovial Fluid - microbiology Synovial Fluid - physiology
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