Ring closure activates yeast γTuRC for species-specific microtubule nucleation

The γ-tubulin ring complex (γTuRC) nucleates microtubules in the cell. The functional, closed state of yeast γTuRC is now visualized, and its microtubule-nucleating activity is found to be species specific. The γ-tubulin ring complex (γTuRC) is the primary microtubule nucleator in cells. γγTuRC is a...

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Veröffentlicht in:	Nature structural & molecular biology 2015-02, Vol.22 (2), p.132-137
Hauptverfasser:	Kollman, Justin M, Greenberg, Charles H, Li, Sam, Moritz, Michelle, Zelter, Alex, Fong, Kimberly K, Fernandez, Jose-Jesus, Sali, Andrej, Kilmartin, John, Davis, Trisha N, Agard, David A
Format:	Artikel
Sprache:	eng
Schlagworte:	101/28 14 14/35 14/63 631/535/1258/1259 631/535/1258/1260 631/80/128/1653 631/80/128/1965 82/80 82/83 Biochemistry Biological Microscopy Life Sciences Membrane Biology Microtubules Microtubules - metabolism Physiological aspects Protein Binding Protein Structure Protein Structure, Quaternary Protein Structure, Secondary Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - metabolism Structure Tubulin - chemistry Tubulin - metabolism Tubulins
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