Adoptive T-cell therapy of prostate cancer targeting the cancer stem cell antigen EpCAM

Adoptive transfer of tumor infiltrating or circulating lymphocytes transduced with tumor antigen receptors has been examined in various clinical trials to treat human cancers. The tumor antigens targeted by transferred lymphocytes affects the efficacy of this therapeutic approach. Because cancer ste...

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Veröffentlicht in:	BMC immunology 2015-01, Vol.16 (1), p.1-1, Article 1
Hauptverfasser:	Deng, Zhenling, Wu, Yanhong, Ma, Wenbo, Zhang, Shuren, Zhang, Yu-Qian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Neoplasm - immunology Care and treatment Cell Adhesion Molecules - immunology Cell Growth Processes Cell Line, Tumor Cytotoxicity, Immunologic Epithelial Cell Adhesion Molecule Genetic aspects Health aspects Humans Immunotherapy, Adoptive Male Metastasis Mice Mice, SCID Molecular Targeted Therapy Neoplasm Metastasis Neoplastic Stem Cells - immunology Prostate cancer Prostatic Neoplasms - immunology Prostatic Neoplasms - therapy Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - metabolism Recombinant Fusion Proteins - genetics Stem cells T cells T-Lymphocytes - immunology T-Lymphocytes - transplantation Xenograft Model Antitumor Assays
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