Diacetyloxyl derivatization of the fibroblast growth factor inhibitor dobesilate enhances its anti-inflammatory, anti-angiogenic and anti-tumoral activities

Dobesilate (2,5-dihydroxyphenyl sulfonate, DHPS) was recently identified as the most potent member of a family of fibroblast growth factor (FGF) inhibitors headed by gentisic acid, one of the main catabolites of aspirin. Although FGFs were first described as inducers of angiogenesis, they were soon...

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Veröffentlicht in:	Journal of translational medicine 2015-02, Vol.13 (1), p.48-48, Article 48
Hauptverfasser:	Angulo, Javier, Cuevas, Pedro, Cuevas, Begoña, El Youssef, Mohammad, Fernández, Argentina, Martínez-Salamanca, Eduardo, González-Corrochano, Rocío, Giménez-Gallego, Guillermo
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Administration, Oral Administration, Topical Analysis Angiogenesis Inhibitors - pharmacology Animals Anti-Inflammatory Agents - pharmacology Antimitotic agents Antineoplastic agents Antineoplastic Agents - pharmacology Aspirin Benzenesulfonates - administration & dosage Benzenesulfonates - chemistry Benzenesulfonates - pharmacology Benzenesulfonates - therapeutic use Care and treatment Cell Line, Tumor COX-2 inhibitors Cyclooxygenase 2 - metabolism Cytokines - metabolism Dermatitis - complications Dermatitis - drug therapy Dermatitis - pathology Development and progression Fibroblast growth factors Fibroblast Growth Factors - antagonists & inhibitors Fibroblast Growth Factors - metabolism Gliomas Health aspects Hydroxides Inflammation Inflammation - complications Inflammation - drug therapy Inflammation - pathology Inflammation Mediators - metabolism Injections, Intraperitoneal Male Mitogens Mitogens - pharmacology Permeability Prostaglandins Rats, Sprague-Dawley
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