Methylation and expression of the tumour suppressor, PRDM5, in colorectal cancer and polyp subgroups

PRDM5 is an epigenetic regulator that has been recognized as an important tumour suppressor gene. Silencing of PRDM5 by promoter hypermethylation has been demonstrated in several cancer types and PRDM5 loss results in upregulation of the Wnt pathway and increased cellular proliferation. PRDM5 has no...

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Veröffentlicht in:	BMC cancer 2015-01, Vol.15 (1), p.20-20, Article 20
Hauptverfasser:	Bond, Catherine E, Bettington, Mark L, Pearson, Sally-Ann, McKeone, Diane M, Leggett, Barbara A, Whitehall, Vicki L J
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biomarkers, Tumor - biosynthesis Biomarkers, Tumor - genetics Cell Line, Tumor Colonic Polyps - genetics Colonic Polyps - pathology Colorectal cancer Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Comparative analysis CpG Islands DNA Methylation - genetics DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - genetics Female Gene Expression Regulation, Neoplastic Gene mutations Genes, Tumor Suppressor Genetic aspects Health aspects Humans Male Methylation Middle Aged Neoplasm Staging Physiological aspects Promoter Regions, Genetic Proto-Oncogene Proteins B-raf - genetics Risk factors RNA, Messenger - biosynthesis Transcription Factors - biosynthesis Transcription Factors - genetics
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