MKK7 mediates miR‐493‐dependent suppression of liver metastasis of colon cancer cells

The prognosis of advanced colon cancer patients is profoundly affected by the presence or absence of liver metastasis. miR‐493 functions as a potent suppressor of liver metastasis, and low‐level miR‐493 expression in human primary colon cancer is associated with an elevated incidence of liver metast...

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Veröffentlicht in:	Cancer science 2014-04, Vol.105 (4), p.425-430
Hauptverfasser:	Sakai, Hiroaki, Sato, Ai, Aihara, Yuki, Ikarashi, Yoshinori, Midorikawa, Yutaka, Kracht, Michael, Nakagama, Hitoshi, Okamoto, Koji
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions Binding Sites Cell Line, Tumor Colon cancer Colonic Neoplasms - genetics Colonic Neoplasms - pathology Colonic Neoplasms - therapy Gene Expression Regulation, Neoplastic Humans JNK Liver Neoplasms - genetics Liver Neoplasms - secondary Liver Neoplasms - therapy MAP Kinase Kinase 7 - genetics MAP Kinase Kinase 7 - metabolism metastasis MicroRNAs - genetics MicroRNAs - metabolism miR‐493 MKK7 Original Receptor, IGF Type 1
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