Characterization of common marmoset dysgerminoma‐like tumor induced by the lentiviral expression of reprogramming factors

Recent generation of induced pluripotent stem (iPSCs) has made a significant impact on the field of human regenerative medicine. Prior to the clinical application of iPSCs, testing of their safety and usefulness must be carried out using reliable animal models of various diseases. In order to genera...

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Veröffentlicht in:	Cancer science 2014-04, Vol.105 (4), p.402-408
Hauptverfasser:	Yamaguchi, Saori, Marumoto, Tomotoshi, Nii, Takenobu, Kawano, Hirotaka, Liao, Jiyuan, Nagai, Yoko, Okada, Michiyo, Takahashi, Atsushi, Inoue, Hiroyuki, Sasaki, Erika, Fujii, Hiroshi, Okano, Shinji, Ebise, Hayao, Sato, Tetsuya, Suyama, Mikita, Okano, Hideyuki, Miura, Yoshie, Tani, Kenzaburo
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormal Karyotype Animal models Animals Callithrix Callithrix jacchus Carcinogenesis - genetics Cell culture Chromosomes Common marmoset Coronary vessels Deoxyribonucleic acid DNA DNA damage Dysgerminoma - genetics Dysgerminoma - pathology Dysgerminoma - therapy FGFR Fibroblast growth factors Fibroblasts Gene Expression Regulation, Neoplastic Genomes Growth factors Humans Induced Pluripotent Stem Cells Inhibitory postsynaptic potentials Karyotypes KLF4 protein Kruppel-Like Factor 4 Kruppel-Like Transcription Factors - biosynthesis Kruppel-Like Transcription Factors - genetics Laboratories Lentivirus Mice Myc protein Oct-4 protein Octamer Transcription Factor-3 - biosynthesis Octamer Transcription Factor-3 - genetics Original Phosphatase Pluripotency Proto-Oncogene Proteins c-myc - biosynthesis Proto-Oncogene Proteins c-myc - genetics regenerating medicine Regenerative medicine reprogramming factor SOXB1 Transcription Factors - biosynthesis SOXB1 Transcription Factors - genetics Stem cells Transcription factors Transduction, Genetic Tumorigenesis Tumors
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