Protein Quality Control and Metabolism: Bidirectional Control in the Heart
The prevalence of heart disease, especially heart failure, continues to increase, and cardiovascular disease remains the leading cause of death worldwide. As cardiomyocytes are essentially irreplaceable, protein quality control is pivotal to cellular homeostasis and, ultimately, cardiac performance....
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| Veröffentlicht in: | Cell metabolism 2015-02, Vol.21 (2), p.215-226 |
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| creator | Wang, Zhao V. Hill, Joseph A. |
| description | The prevalence of heart disease, especially heart failure, continues to increase, and cardiovascular disease remains the leading cause of death worldwide. As cardiomyocytes are essentially irreplaceable, protein quality control is pivotal to cellular homeostasis and, ultimately, cardiac performance. Three evolutionarily conserved mechanisms—autophagy, the unfolded protein response, and the ubiquitin-proteasome system—act in concert to degrade misfolded proteins and eliminate defective organelles. Recent advances have revealed that these mechanisms are intimately associated with cellular metabolism. Going forward, comprehensive understanding of the role of protein quality control mechanisms in cardiac pathology will require integration of metabolic pathways and metabolic control.
Wang and Hill review bidirectional cross-talk between protein quality control mechanisms within the cardiac myocyte, including autophagy, the unfolded protein response (UPR), and the ubiquitin-proteasome system, and cardiac metabolism. They discuss implications in cardiovascular physiology and pathophysiology and highlight the intricate interplay between these critical pathways. |
| doi_str_mv | 10.1016/j.cmet.2015.01.016 |
| format | Article |
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Wang and Hill review bidirectional cross-talk between protein quality control mechanisms within the cardiac myocyte, including autophagy, the unfolded protein response (UPR), and the ubiquitin-proteasome system, and cardiac metabolism. They discuss implications in cardiovascular physiology and pathophysiology and highlight the intricate interplay between these critical pathways.</description><identifier>ISSN: 1550-4131</identifier><identifier>EISSN: 1932-7420</identifier><identifier>DOI: 10.1016/j.cmet.2015.01.016</identifier><identifier>PMID: 25651176</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Heart Diseases - metabolism ; Heart Diseases - pathology ; Humans ; Myocardium - metabolism ; Myocardium - pathology ; Proteins - metabolism</subject><ispartof>Cell metabolism, 2015-02, Vol.21 (2), p.215-226</ispartof><rights>2015 Elsevier Inc.</rights><rights>Copyright © 2015 Elsevier Inc. All rights reserved.</rights><rights>2015 Elsevier Inc. All rights reserved. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c521t-22a6c2d2ee528641adfd80cff577811f31d452334893ec9eec0df4eb8c28c18a3</citedby><cites>FETCH-LOGICAL-c521t-22a6c2d2ee528641adfd80cff577811f31d452334893ec9eec0df4eb8c28c18a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cmet.2015.01.016$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25651176$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Zhao V.</creatorcontrib><creatorcontrib>Hill, Joseph A.</creatorcontrib><title>Protein Quality Control and Metabolism: Bidirectional Control in the Heart</title><title>Cell metabolism</title><addtitle>Cell Metab</addtitle><description>The prevalence of heart disease, especially heart failure, continues to increase, and cardiovascular disease remains the leading cause of death worldwide. As cardiomyocytes are essentially irreplaceable, protein quality control is pivotal to cellular homeostasis and, ultimately, cardiac performance. Three evolutionarily conserved mechanisms—autophagy, the unfolded protein response, and the ubiquitin-proteasome system—act in concert to degrade misfolded proteins and eliminate defective organelles. Recent advances have revealed that these mechanisms are intimately associated with cellular metabolism. Going forward, comprehensive understanding of the role of protein quality control mechanisms in cardiac pathology will require integration of metabolic pathways and metabolic control.
Wang and Hill review bidirectional cross-talk between protein quality control mechanisms within the cardiac myocyte, including autophagy, the unfolded protein response (UPR), and the ubiquitin-proteasome system, and cardiac metabolism. They discuss implications in cardiovascular physiology and pathophysiology and highlight the intricate interplay between these critical pathways.</description><subject>Animals</subject><subject>Heart Diseases - metabolism</subject><subject>Heart Diseases - pathology</subject><subject>Humans</subject><subject>Myocardium - metabolism</subject><subject>Myocardium - pathology</subject><subject>Proteins - metabolism</subject><issn>1550-4131</issn><issn>1932-7420</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kd1LHDEUxUNRqrX9B_og8-jLbHPzNTMigi71C0tbaJ9DNrlTs8xMNMkK_vdmWbvoi3AhgfzOyeUcQr4CnQEF9W05syPmGaMgZxTKqA9kHzrO6kYwulPuUtJaAIc98imlJaVc8Y5_JHtMKgnQqH1y8yuGjH6qfq_M4PNTNQ9TjmGozOSqH5jNIgw-jcfVuXc-os0-TGbYUkWY77C6QhPzZ7LbmyHhl5fzgPy9-P5nflXf_ry8np_d1lYyyDVjRlnmGKJkrRJgXO9aavteNk0L0HNwQjLORdtxtB2ipa4XuGgtay20hh-Q043v_WoxorNYVjGDvo9-NPFJB-P125fJ3-l_4VELDo1seDE4ejGI4WGFKevRJ4vDYCYMq6RBKSk6wfkaZRvUxpBSxH77DVC9LkEv9boEvS5BUyijiujw9YJbyf_UC3CyAbDE9Ogx6mQ9ThY3EWsX_Hv-z_iOmbA</recordid><startdate>20150203</startdate><enddate>20150203</enddate><creator>Wang, Zhao V.</creator><creator>Hill, Joseph A.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150203</creationdate><title>Protein Quality Control and Metabolism: Bidirectional Control in the Heart</title><author>Wang, Zhao V. ; Hill, Joseph A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c521t-22a6c2d2ee528641adfd80cff577811f31d452334893ec9eec0df4eb8c28c18a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Heart Diseases - metabolism</topic><topic>Heart Diseases - pathology</topic><topic>Humans</topic><topic>Myocardium - metabolism</topic><topic>Myocardium - pathology</topic><topic>Proteins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Zhao V.</creatorcontrib><creatorcontrib>Hill, Joseph A.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cell metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Zhao V.</au><au>Hill, Joseph A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protein Quality Control and Metabolism: Bidirectional Control in the Heart</atitle><jtitle>Cell metabolism</jtitle><addtitle>Cell Metab</addtitle><date>2015-02-03</date><risdate>2015</risdate><volume>21</volume><issue>2</issue><spage>215</spage><epage>226</epage><pages>215-226</pages><issn>1550-4131</issn><eissn>1932-7420</eissn><abstract>The prevalence of heart disease, especially heart failure, continues to increase, and cardiovascular disease remains the leading cause of death worldwide. As cardiomyocytes are essentially irreplaceable, protein quality control is pivotal to cellular homeostasis and, ultimately, cardiac performance. Three evolutionarily conserved mechanisms—autophagy, the unfolded protein response, and the ubiquitin-proteasome system—act in concert to degrade misfolded proteins and eliminate defective organelles. Recent advances have revealed that these mechanisms are intimately associated with cellular metabolism. Going forward, comprehensive understanding of the role of protein quality control mechanisms in cardiac pathology will require integration of metabolic pathways and metabolic control.
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| ispartof | Cell metabolism, 2015-02, Vol.21 (2), p.215-226 |
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| source | MEDLINE; Cell Press Free Archives; ScienceDirect Journals (5 years ago - present); EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Heart Diseases - metabolism Heart Diseases - pathology Humans Myocardium - metabolism Myocardium - pathology Proteins - metabolism |
| title | Protein Quality Control and Metabolism: Bidirectional Control in the Heart |
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