Temporal and spatial regulation of translation in the mammalian oocyte via the mTOR–eIF4F pathway

The fully grown mammalian oocyte is transcriptionally quiescent and utilizes only transcripts synthesized and stored during early development. However, we find that an abundant RNA population is retained in the oocyte nucleus and contains specific mRNAs important for meiotic progression. Here we sho...

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Veröffentlicht in:	Nature communications 2015-01, Vol.6 (1), p.6078-6078, Article 6078
Hauptverfasser:	Susor, Andrej, Jansova, Denisa, Cerna, Renata, Danylevska, Anna, Anger, Martin, Toralova, Tereza, Malik, Radek, Supolikova, Jaroslava, Cook, Matthew S., Oh, Jeong Su, Kubelka, Michal
Format:	Artikel
Sprache:	eng
Schlagworte:	13 14 14/1 14/19 14/32 14/34 14/35 14/63 38 38/5 38/90 631/136/2086 631/80/386 631/80/458 631/80/641/1633 82 82/29 Animals Chromosomes, Mammalian - metabolism Down-Regulation Eukaryotic Initiation Factor-4F - metabolism Fertilization Genomic Instability Humanities and Social Sciences Humans Mammals - metabolism Meiosis Mice multidisciplinary Nuclear Envelope - metabolism Oocytes - metabolism Protein Biosynthesis RNA Caps - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Science Science (multidisciplinary) Signal Transduction Time Factors TOR Serine-Threonine Kinases - metabolism
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