Age-related decline in ovarian follicle stocks differ between chimpanzees (Pan troglodytes) and humans
Similarity in oldest parturitions in humans and great apes suggests that we maintain ancestral rates of ovarian aging. Consistent with that hypothesis, previous counts of primordial follicles in postmortem ovarian sections from chimpanzees ( Pan troglodytes ) showed follicle stock decline at the sam...
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| Veröffentlicht in: | AGE 2015-02, Vol.37 (1), p.9746-9746, Article 10 |
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| creator | Cloutier, Christina T. Coxworth, James E. Hawkes, Kristen |
| description | Similarity in oldest parturitions in humans and great apes suggests that we maintain ancestral rates of ovarian aging. Consistent with that hypothesis, previous counts of primordial follicles in postmortem ovarian sections from chimpanzees (
Pan troglodytes
) showed follicle stock decline at the same rate that human stocks decline across the same ages. Here, we correct that finding with a chimpanzee sample more than three times larger than the previous one, which also allows comparison into older ages. Analyses show depletion rates similar until about age 35, but after 35, the human counts continue to fall with age, while the change is much less steep in chimpanzees. This difference implicates likely effects on ovarian dynamics from other physiological systems that are senescing at different rates, and, potentially, different perimenopausal experience for chimpanzees and humans. |
| doi_str_mv | 10.1007/s11357-015-9746-4 |
| format | Article |
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Pan troglodytes
) showed follicle stock decline at the same rate that human stocks decline across the same ages. Here, we correct that finding with a chimpanzee sample more than three times larger than the previous one, which also allows comparison into older ages. Analyses show depletion rates similar until about age 35, but after 35, the human counts continue to fall with age, while the change is much less steep in chimpanzees. This difference implicates likely effects on ovarian dynamics from other physiological systems that are senescing at different rates, and, potentially, different perimenopausal experience for chimpanzees and humans.</description><identifier>ISSN: 0161-9152</identifier><identifier>ISSN: 2509-2715</identifier><identifier>EISSN: 1574-4647</identifier><identifier>EISSN: 2509-2723</identifier><identifier>DOI: 10.1007/s11357-015-9746-4</identifier><identifier>PMID: 25651885</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Adolescent ; Adult ; Age ; Aging ; Aging - physiology ; Animals ; Biomedical and Life Sciences ; Blood & organ donations ; Cell Biology ; Child ; Child, Preschool ; Female ; Females ; Fertility ; Follicles ; Geriatrics/Gerontology ; Hominids ; Humans ; Hypotheses ; Infant ; Infant, Newborn ; Laboratory animals ; Life Sciences ; Middle Aged ; Molecular Medicine ; Monkeys & apes ; Ovarian Follicle - physiology ; Ovarian Reserve - physiology ; Ovaries ; Pan troglodytes ; Physiology ; Young Adult</subject><ispartof>AGE, 2015-02, Vol.37 (1), p.9746-9746, Article 10</ispartof><rights>American Aging Association 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-44009f6269f4af161b550a22b499273914a54c76f1777b58d3e21ce4f8b303933</citedby><cites>FETCH-LOGICAL-c540t-44009f6269f4af161b550a22b499273914a54c76f1777b58d3e21ce4f8b303933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317403/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317403/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,725,778,782,883,27907,27908,53774,53776</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25651885$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cloutier, Christina T.</creatorcontrib><creatorcontrib>Coxworth, James E.</creatorcontrib><creatorcontrib>Hawkes, Kristen</creatorcontrib><title>Age-related decline in ovarian follicle stocks differ between chimpanzees (Pan troglodytes) and humans</title><title>AGE</title><addtitle>AGE</addtitle><addtitle>Age (Dordr)</addtitle><description>Similarity in oldest parturitions in humans and great apes suggests that we maintain ancestral rates of ovarian aging. Consistent with that hypothesis, previous counts of primordial follicles in postmortem ovarian sections from chimpanzees (
Pan troglodytes
) showed follicle stock decline at the same rate that human stocks decline across the same ages. Here, we correct that finding with a chimpanzee sample more than three times larger than the previous one, which also allows comparison into older ages. Analyses show depletion rates similar until about age 35, but after 35, the human counts continue to fall with age, while the change is much less steep in chimpanzees. This difference implicates likely effects on ovarian dynamics from other physiological systems that are senescing at different rates, and, potentially, different perimenopausal experience for chimpanzees and humans.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Aging</subject><subject>Aging - physiology</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Blood & organ donations</subject><subject>Cell Biology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Females</subject><subject>Fertility</subject><subject>Follicles</subject><subject>Geriatrics/Gerontology</subject><subject>Hominids</subject><subject>Humans</subject><subject>Hypotheses</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Laboratory animals</subject><subject>Life Sciences</subject><subject>Middle Aged</subject><subject>Molecular Medicine</subject><subject>Monkeys & apes</subject><subject>Ovarian Follicle - physiology</subject><subject>Ovarian Reserve - physiology</subject><subject>Ovaries</subject><subject>Pan troglodytes</subject><subject>Physiology</subject><subject>Young Adult</subject><issn>0161-9152</issn><issn>2509-2715</issn><issn>1574-4647</issn><issn>2509-2723</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kU1rVDEUhoModhz9AW4k4KYuruY7NxuhFLVCQRe6Drm5JzOpd5IxubdSf70Zpi1VcJXFec6b9_Ag9JKSt5QQ_a5SyqXuCJWd0UJ14hFaUalFJ5TQj9GKUEU7QyU7Qc9qvSJESt6zp-iESSVp38sVCmcb6ApMboYRj-CnmADHhPO1K9ElHPI0RT8BrnP2PyoeYwhQ8ADzL4CE_Tbu9i79Bqj49Gvj55I3Ux5vZqhvsEsj3i47l-pz9CS4qcKL23eNvn_88O38orv88unz-dll56UgcycEISYopkwQLrT2g5TEMTYIY5jmhgonhdcqUK31IPuRA6MeROgHTrjhfI3eH3P3y7CD0UOai5vsvsSdKzc2u2j_nqS4tZt8bQWnWpBDwOltQMk_F6iz3cXqYZpcgrxUS5VkQhqhTENf_4Ne5aWkdl6jFOO6741uFD1SvuRaC4T7MpTYg0V7tGibRXuw2Kqs0auHV9xv3GlrADsCtY3SBsqDr_-b-geHMafk</recordid><startdate>20150201</startdate><enddate>20150201</enddate><creator>Cloutier, Christina T.</creator><creator>Coxworth, James E.</creator><creator>Hawkes, Kristen</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7QG</scope><scope>7RV</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7WY</scope><scope>7WZ</scope><scope>7X7</scope><scope>7XB</scope><scope>87Z</scope><scope>88E</scope><scope>88J</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FL</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BEZIV</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FRNLG</scope><scope>FYUFA</scope><scope>F~G</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HEHIP</scope><scope>K60</scope><scope>K6~</scope><scope>K9.</scope><scope>KB0</scope><scope>L.-</scope><scope>M0C</scope><scope>M0S</scope><scope>M1P</scope><scope>M2R</scope><scope>M2S</scope><scope>NAPCQ</scope><scope>PQBIZ</scope><scope>PQBZA</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYYUZ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150201</creationdate><title>Age-related decline in ovarian follicle stocks differ between chimpanzees (Pan troglodytes) and humans</title><author>Cloutier, Christina T. ; Coxworth, James E. ; Hawkes, Kristen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c540t-44009f6269f4af161b550a22b499273914a54c76f1777b58d3e21ce4f8b303933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age</topic><topic>Aging</topic><topic>Aging - physiology</topic><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Blood & organ donations</topic><topic>Cell Biology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Females</topic><topic>Fertility</topic><topic>Follicles</topic><topic>Geriatrics/Gerontology</topic><topic>Hominids</topic><topic>Humans</topic><topic>Hypotheses</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Laboratory animals</topic><topic>Life Sciences</topic><topic>Middle Aged</topic><topic>Molecular Medicine</topic><topic>Monkeys & apes</topic><topic>Ovarian Follicle - physiology</topic><topic>Ovarian Reserve - physiology</topic><topic>Ovaries</topic><topic>Pan troglodytes</topic><topic>Physiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cloutier, Christina T.</creatorcontrib><creatorcontrib>Coxworth, James E.</creatorcontrib><creatorcontrib>Hawkes, Kristen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>ABI/INFORM Collection</collection><collection>ABI/INFORM Global (PDF only)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ABI/INFORM Global (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ABI/INFORM Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Business Premium Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Business Premium Collection (Alumni)</collection><collection>Health Research Premium Collection</collection><collection>ABI/INFORM Global (Corporate)</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Sociology Collection</collection><collection>ProQuest Business Collection (Alumni Edition)</collection><collection>ProQuest Business Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ABI/INFORM Professional Advanced</collection><collection>ABI/INFORM Global</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Social Science Database</collection><collection>Sociology Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Business</collection><collection>ProQuest One Business (Alumni)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ABI/INFORM Collection China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>AGE</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cloutier, Christina T.</au><au>Coxworth, James E.</au><au>Hawkes, Kristen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Age-related decline in ovarian follicle stocks differ between chimpanzees (Pan troglodytes) and humans</atitle><jtitle>AGE</jtitle><stitle>AGE</stitle><addtitle>Age (Dordr)</addtitle><date>2015-02-01</date><risdate>2015</risdate><volume>37</volume><issue>1</issue><spage>9746</spage><epage>9746</epage><pages>9746-9746</pages><artnum>10</artnum><issn>0161-9152</issn><issn>2509-2715</issn><eissn>1574-4647</eissn><eissn>2509-2723</eissn><abstract>Similarity in oldest parturitions in humans and great apes suggests that we maintain ancestral rates of ovarian aging. Consistent with that hypothesis, previous counts of primordial follicles in postmortem ovarian sections from chimpanzees (
Pan troglodytes
) showed follicle stock decline at the same rate that human stocks decline across the same ages. Here, we correct that finding with a chimpanzee sample more than three times larger than the previous one, which also allows comparison into older ages. Analyses show depletion rates similar until about age 35, but after 35, the human counts continue to fall with age, while the change is much less steep in chimpanzees. This difference implicates likely effects on ovarian dynamics from other physiological systems that are senescing at different rates, and, potentially, different perimenopausal experience for chimpanzees and humans.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>25651885</pmid><doi>10.1007/s11357-015-9746-4</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Age Aging Aging - physiology Animals Biomedical and Life Sciences Blood & organ donations Cell Biology Child Child, Preschool Female Females Fertility Follicles Geriatrics/Gerontology Hominids Humans Hypotheses Infant Infant, Newborn Laboratory animals Life Sciences Middle Aged Molecular Medicine Monkeys & apes Ovarian Follicle - physiology Ovarian Reserve - physiology Ovaries Pan troglodytes Physiology Young Adult |
| title | Age-related decline in ovarian follicle stocks differ between chimpanzees (Pan troglodytes) and humans |
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