Computer-Aided Discovery of Trypanosoma brucei RNA-Editing Terminal Uridylyl Transferase 2 Inhibitors

Human African trypanosomiasis (HAT) is a major health problem in sub‐Saharan Africa caused by Trypanosoma brucei infection. Current HAT drugs are difficult to administer and not effective against all parasite species at different stages of the disease which indicates an unmet pharmaceutical need. Tb...

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Veröffentlicht in:	Chemical biology & drug design 2014-08, Vol.84 (2), p.131-139
Hauptverfasser:	Demir, Özlem, Labaied, Mehdi, Merritt, Chris, Stuart, Ken, Amaro, Rommie E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Computer-Aided Design Drug Discovery Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology HAT human African trypanosomiasis Humans Molecular Docking Simulation Molecular Dynamics Simulation RET2 RNA Nucleotidyltransferases - antagonists & inhibitors RNA Nucleotidyltransferases - metabolism sleeping sickness Trypanocidal Agents - chemistry Trypanocidal Agents - pharmacology Trypanosoma brucei Trypanosoma brucei brucei - drug effects Trypanosoma brucei brucei - enzymology trypanosomes Trypanosomiasis, African - drug therapy Trypanosomiasis, African - enzymology Trypanosomiasis, African - parasitology TUTase virtual screening
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