Crystal Structures of Phosphite Dehydrogenase Provide Insights into Nicotinamide Cofactor Regeneration

The enzyme phosphite dehydrogenase (PTDH) catalyzes the NAD+-dependent conversion of phosphite to phosphate and represents the first biological catalyst that has been shown to conduct the enzymatic oxidation of phosphorus. Despite investigation for more than a decade into both the mechanism of its u...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemistry (Easton) 2012-05, Vol.51 (21), p.4263-4270
Hauptverfasser:	Zou, Yaozhong, Zhang, Houjin, Brunzelle, Joseph S, Johannes, Tyler W, Woodyer, Ryan, Hung, John E, Nair, Nikhil, van der Donk, Wilfred A, Zhao, Huimin, Nair, Satish K
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES active sites Amino Acid Substitution Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism BASIC BIOLOGICAL SCIENCES Binding, Competitive CATALYSTS Catalytic Domain - genetics CRYSTAL STRUCTURE Crystallography, X-Ray enzyme activity Enzyme Inhibitors - pharmacology Enzyme Stability ENZYMES Ligands Models, Molecular Mutagenesis, Site-Directed NAD - metabolism NADH, NADPH Oxidoreductases - antagonists & inhibitors NADH, NADPH Oxidoreductases - chemistry NADH, NADPH Oxidoreductases - genetics NADH, NADPH Oxidoreductases - metabolism NICOTINAMIDE OXIDATION OXIDOREDUCTASES PHOSPHATES PHOSPHOROUS ACID PHOSPHORUS Protein Conformation Protein Engineering Pseudomonas stutzeri - enzymology Pseudomonas stutzeri - genetics Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism REGENERATION RESIDUES RESOLUTION Sulfites - pharmacology thermal stability
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!