High prevalence of vitamin A deficiency in Crohn’s disease patients according to serum retinol levels and the relative dose-response test
AIM:To assess the vitamin A status of patients with Crohn’s disease(CD) by evaluating serum retinol levels and the relative dose response(RDR) test(liver retinol stores).METHODS:Vitamin A nutritional status was measured by serum retinol obtained by high performance liquid chromatography and the RDR...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2015-02, Vol.21 (5), p.1614-1620 |
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| container_title | World journal of gastroenterology : WJG |
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| creator | Soares-Mota, Márcia Silva, Tianny A Gomes, Luanda M Pinto, Marco A S Mendonça, Laura M C Farias, Maria Lúcia F Nunes, Tiago Ramalho, Andrea Zaltman, Cyrla |
| description | AIM:To assess the vitamin A status of patients with Crohn’s disease(CD) by evaluating serum retinol levels and the relative dose response(RDR) test(liver retinol stores).METHODS:Vitamin A nutritional status was measured by serum retinol obtained by high performance liquid chromatography and the RDR test for evaluation of the hepatic stores.Body composition was performed by densitometry by dual-energy X-ray absorptiometry.Vitamin A dietary intake was assessed from a semiquantitative food frequency questionnaire.RESULTS:This study included 38 CD patients and 33 controls.Low serum retinol concentrations were detected in 29% of CD patients vs 15% in controls(P < 0.005).The RDR test was positive in 37% of CD patients vs 12% in controls,which indicated inadequate hepatic vitamin A stores(P < 0.005).Individuals with hypovitaminosis A had lower BMI and body fat compared with those without this deficiency.There was no association between vitamin A deficiency and its dietary intake,ileal location,presence of disease activity and prior bowel resections.CONCLUSION:Patients with CD have higher prevalence of vitamin A deficiency,as assessed by two independent methods. |
| doi_str_mv | 10.3748/wjg.v21.i5.1614 |
| format | Article |
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Published by Baishideng Publishing Group Inc. 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0.005).The RDR test was positive in 37% of CD patients vs 12% in controls,which indicated inadequate hepatic vitamin A stores(P &lt; 0.005).Individuals with hypovitaminosis A had lower BMI and body fat compared with those without this deficiency.There was no association between vitamin A deficiency and its dietary intake,ileal location,presence of disease activity and prior bowel resections.CONCLUSION:Patients with CD have higher prevalence of vitamin A deficiency,as assessed by two independent methods.</description><subject>A;Serum</subject><subject>Absorptiometry, Photon</subject><subject>Adiposity</subject><subject>Adult</subject><subject>Biomarkers - blood</subject><subject>Body Mass Index</subject><subject>Brazil - epidemiology</subject><subject>Case-Control Studies</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Crohn Disease - diagnosis</subject><subject>Crohn Disease - epidemiology</subject><subject>Crohn Disease - physiopathology</subject><subject>Crohn’s</subject><subject>Cross-Sectional Studies</subject><subject>disease;Vitamin</subject><subject>Female</subject><subject>Humans</subject><subject>Liver - chemistry</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nutrition Assessment</subject><subject>Nutritional Status</subject><subject>Observational Study</subject><subject>Predictive Value of Tests</subject><subject>Prevalence</subject><subject>retinol;Relative</subject><subject>Surveys and Questionnaires</subject><subject>Vitamin A - blood</subject><subject>Vitamin A Deficiency - blood</subject><subject>Vitamin A Deficiency - diagnosis</subject><subject>Vitamin A Deficiency - epidemiology</subject><subject>Vitamin A Deficiency - physiopathology</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkc9u1DAQxi0EokvhzA35yCVb_43jC1K1AopUiQucrcSeJK4Se2tng3rjzhPwejwJXrqswJJleeY3n8fzIfSaki1Xorn6djdsV0a3Xm5pTcUTtGGM6oo1gjxFG0qIqjRn6gK9yPmOEMa5ZM_RBZN1zVVDN-jHjR9GvE-wthMECzj2ePVLO_uAr7GD3ltf4g-43HcpjuHX958ZO5-hzYD37VKyS8attTE5Hwa8RJwhHWacYPEhTniCFaZCBIeXEUp4KkUrYBczVAnyPoaitEBeXqJnfTtleHU6L9HXD--_7G6q288fP-2ubysruFoqLQBACQld3VlhnWCdbEqq1j0XVmlbC3Bad0pT6lTPSSe1aGomnesZ7xi_RO8edfeHbgZnyw9SO5l98nObHkxsvfk_E_xohrgawcuQiSgCb08CKd4fSudm9tnCNLUB4iEbWktOWaMILejVI2pTzDlBf36GEnO00BQLTbHQeGmOFpaKN_92d-b_elYAfpIcYxjuy9DPjCbNcWlJRCO05KL5s4mU_DetQaye</recordid><startdate>20150207</startdate><enddate>20150207</enddate><creator>Soares-Mota, Márcia</creator><creator>Silva, Tianny A</creator><creator>Gomes, Luanda M</creator><creator>Pinto, Marco A S</creator><creator>Mendonça, Laura M C</creator><creator>Farias, Maria Lúcia F</creator><creator>Nunes, Tiago</creator><creator>Ramalho, Andrea</creator><creator>Zaltman, Cyrla</creator><general>Baishideng Publishing Group Inc</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150207</creationdate><title>High prevalence of vitamin A deficiency in Crohn’s disease patients according to serum retinol levels and the relative dose-response test</title><author>Soares-Mota, Márcia ; 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0.005).The RDR test was positive in 37% of CD patients vs 12% in controls,which indicated inadequate hepatic vitamin A stores(P &lt; 0.005).Individuals with hypovitaminosis A had lower BMI and body fat compared with those without this deficiency.There was no association between vitamin A deficiency and its dietary intake,ileal location,presence of disease activity and prior bowel resections.CONCLUSION:Patients with CD have higher prevalence of vitamin A deficiency,as assessed by two independent methods.</abstract><cop>United States</cop><pub>Baishideng Publishing Group Inc</pub><pmid>25663781</pmid><doi>10.3748/wjg.v21.i5.1614</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Baishideng "World Journal of" online journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | A Serum Absorptiometry, Photon Adiposity Adult Biomarkers - blood Body Mass Index Brazil - epidemiology Case-Control Studies Chromatography, High Pressure Liquid Crohn Disease - diagnosis Crohn Disease - epidemiology Crohn Disease - physiopathology Crohn’s Cross-Sectional Studies disease Vitamin Female Humans Liver - chemistry Male Middle Aged Nutrition Assessment Nutritional Status Observational Study Predictive Value of Tests Prevalence retinol Relative Surveys and Questionnaires Vitamin A - blood Vitamin A Deficiency - blood Vitamin A Deficiency - diagnosis Vitamin A Deficiency - epidemiology Vitamin A Deficiency - physiopathology |
| title | High prevalence of vitamin A deficiency in Crohn’s disease patients according to serum retinol levels and the relative dose-response test |
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