Oxidative stress in portal hypertension-induced rats with particular emphasis on nitric oxide and trace metals
AIM: To investigate the oxidative-stress-related changes in rats with portal hypertension with particular emphasis on nitric oxide (NO) and trace metals. METHODS: Cirrhosis was induced by partial portal vein ligation (PVL) in Wistar rats. The lipid peroxidation marker (malondialdehyde, MDA), antioxi...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2005-06, Vol.11 (23), p.3570-3573 |
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| creator | Izzet, Titiz Osman, Krand Ethem, Unal Nihat, Yavuz Ramazan, Kusaslan Mustafa, Dogan Hafize, Uzun Riza, Kiziler Ali Birsen, Aydemir Habibe, Genc Seval, Aydin Gonul, Simsek |
| description | AIM: To investigate the oxidative-stress-related changes in rats with portal hypertension with particular emphasis on nitric oxide (NO) and trace metals. METHODS: Cirrhosis was induced by partial portal vein ligation (PVL) in Wistar rats. The lipid peroxidation marker (malondialdehyde, MDA), antioxidant defense enzymes including superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), and agents known to have antioxidant features including nitric oxide (NO), zinc (Zn), copper (Cu) were determined both in serum and in liver tissue at 4 wk after surgery in PVL and sham-operated rats. Portal pressure of all experimental animals was measured. MDA was detected by thiobarbituric acid reactivity assay.SOD activity was determined by inhibition of nitroblue tetrazolium reduction with xanthine/xanthine oxidase usedas a superoxide generator. CAT activity was determined by the breakdown of hydrogen peroxide. GSH concentrations were measured by using metaphosphoric acid for protein precipitation and 5'-5'-dithio-bis-2-nitrobenzoic acid for color development. NO was detected by the Griess method after reduction of nitrate to nitrite with nitrate reductase, and the concentrations of Zn and Cu were measured by a Shimadzu 680 AA atomic absorption spectrometer. Histopathological confirmation was done under lightmicroscope. Statistical analyses were done by Student's t-test, and significance of the difference was tested by the unpaired Mann-Whitney test. P |
| doi_str_mv | 10.3748/wjg.v11.i23.3570 |
| format | Article |
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METHODS: Cirrhosis was induced by partial portal vein ligation (PVL) in Wistar rats. The lipid peroxidation marker (malondialdehyde, MDA), antioxidant defense enzymes including superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), and agents known to have antioxidant features including nitric oxide (NO), zinc (Zn), copper (Cu) were determined both in serum and in liver tissue at 4 wk after surgery in PVL and sham-operated rats. Portal pressure of all experimental animals was measured. MDA was detected by thiobarbituric acid reactivity assay.SOD activity was determined by inhibition of nitroblue tetrazolium reduction with xanthine/xanthine oxidase usedas a superoxide generator. CAT activity was determined by the breakdown of hydrogen peroxide. GSH concentrations were measured by using metaphosphoric acid for protein precipitation and 5'-5'-dithio-bis-2-nitrobenzoic acid for color development. NO was detected by the Griess method after reduction of nitrate to nitrite with nitrate reductase, and the concentrations of Zn and Cu were measured by a Shimadzu 680 AA atomic absorption spectrometer. Histopathological confirmation was done under lightmicroscope. Statistical analyses were done by Student's t-test, and significance of the difference was tested by the unpaired Mann-Whitney test. P<0.05 was considered statistically significant.RESULTS: Histopathological studies confirmed PVLinduced cirrhotic changes. There was a statistically significant difference in portal pressure between PVL andcont rol groups (P<0.001). The results showed significant increases in the levels of MDA and NO in both tissue and serum (P<0.05 and P<0.001, respectively in tissue; P<0.001 for each in serum), and Zn only in tissue (P<0.001)in rats with PVL compared with sham-operated rats. Besides, PVL rats exhibited reduced plasma and tissue GSH, CAT, SOD (P<0.001 for each). Serum and tissue Cuconcentration did not change. CONCLUSION: Our findings suggest that PVL in rats induces important biochemical and molecular changes related to oxidative stress in the liver.]]></description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v11.i23.3570</identifier><identifier>PMID: 15962377</identifier><language>eng</language><publisher>United States: Department of Surgery, Haydarpasa Numune Training and Research Hospital, Istanbul,Turkey%Department of Surgery, Cerrahpasa Faculty of Medicine, Istanbul University,Istanbul, Turkey%Department of Biochemistry, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey%Department of Biophysics, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul,Turkey%Department of Physiology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey</publisher><subject>Animals ; Antioxidants - pharmacology ; Brief Reports ; Copper - blood ; Copper - metabolism ; Hypertension, Portal - physiopathology ; Lipid Peroxidation ; Liver - metabolism ; Liver - physiopathology ; Male ; Nitric Oxide - blood ; Nitric Oxide - metabolism ; Oxidative Stress ; Portal Vein - pathology ; Rats ; Rats, Wistar ; Trace Elements - blood ; Trace Elements - metabolism ; Zinc - blood ; Zinc - metabolism ; 一氧化氮 ; 动物实验 ; 氧化损伤 ; 肝门静脉高压</subject><ispartof>World journal of gastroenterology : WJG, 2005-06, Vol.11 (23), p.3570-3573</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><rights>2005 Baishideng Publishing Group Inc. All rights reserved. 2005</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-89784d08120017677432cef6217eb56c7cbca2284683259a479a63cde44843343</citedby><cites>FETCH-LOGICAL-c450t-89784d08120017677432cef6217eb56c7cbca2284683259a479a63cde44843343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84123X/84123X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315963/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315963/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15962377$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Izzet, Titiz</creatorcontrib><creatorcontrib>Osman, Krand</creatorcontrib><creatorcontrib>Ethem, Unal</creatorcontrib><creatorcontrib>Nihat, Yavuz</creatorcontrib><creatorcontrib>Ramazan, Kusaslan</creatorcontrib><creatorcontrib>Mustafa, Dogan</creatorcontrib><creatorcontrib>Hafize, Uzun</creatorcontrib><creatorcontrib>Riza, Kiziler Ali</creatorcontrib><creatorcontrib>Birsen, Aydemir</creatorcontrib><creatorcontrib>Habibe, Genc</creatorcontrib><creatorcontrib>Seval, Aydin</creatorcontrib><creatorcontrib>Gonul, Simsek</creatorcontrib><title>Oxidative stress in portal hypertension-induced rats with particular emphasis on nitric oxide and trace metals</title><title>World journal of gastroenterology : WJG</title><addtitle>World Journal of Gastroenterology</addtitle><description><![CDATA[AIM: To investigate the oxidative-stress-related changes in rats with portal hypertension with particular emphasis on nitric oxide (NO) and trace metals. METHODS: Cirrhosis was induced by partial portal vein ligation (PVL) in Wistar rats. The lipid peroxidation marker (malondialdehyde, MDA), antioxidant defense enzymes including superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), and agents known to have antioxidant features including nitric oxide (NO), zinc (Zn), copper (Cu) were determined both in serum and in liver tissue at 4 wk after surgery in PVL and sham-operated rats. Portal pressure of all experimental animals was measured. MDA was detected by thiobarbituric acid reactivity assay.SOD activity was determined by inhibition of nitroblue tetrazolium reduction with xanthine/xanthine oxidase usedas a superoxide generator. CAT activity was determined by the breakdown of hydrogen peroxide. GSH concentrations were measured by using metaphosphoric acid for protein precipitation and 5'-5'-dithio-bis-2-nitrobenzoic acid for color development. NO was detected by the Griess method after reduction of nitrate to nitrite with nitrate reductase, and the concentrations of Zn and Cu were measured by a Shimadzu 680 AA atomic absorption spectrometer. Histopathological confirmation was done under lightmicroscope. Statistical analyses were done by Student's t-test, and significance of the difference was tested by the unpaired Mann-Whitney test. P<0.05 was considered statistically significant.RESULTS: Histopathological studies confirmed PVLinduced cirrhotic changes. There was a statistically significant difference in portal pressure between PVL andcont rol groups (P<0.001). The results showed significant increases in the levels of MDA and NO in both tissue and serum (P<0.05 and P<0.001, respectively in tissue; P<0.001 for each in serum), and Zn only in tissue (P<0.001)in rats with PVL compared with sham-operated rats. Besides, PVL rats exhibited reduced plasma and tissue GSH, CAT, SOD (P<0.001 for each). Serum and tissue Cuconcentration did not change. CONCLUSION: Our findings suggest that PVL in rats induces important biochemical and molecular changes related to oxidative stress in the liver.]]></description><subject>Animals</subject><subject>Antioxidants - pharmacology</subject><subject>Brief Reports</subject><subject>Copper - blood</subject><subject>Copper - metabolism</subject><subject>Hypertension, Portal - physiopathology</subject><subject>Lipid Peroxidation</subject><subject>Liver - metabolism</subject><subject>Liver - physiopathology</subject><subject>Male</subject><subject>Nitric Oxide - blood</subject><subject>Nitric Oxide - metabolism</subject><subject>Oxidative Stress</subject><subject>Portal Vein - pathology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Trace Elements - blood</subject><subject>Trace Elements - metabolism</subject><subject>Zinc - blood</subject><subject>Zinc - metabolism</subject><subject>一氧化氮</subject><subject>动物实验</subject><subject>氧化损伤</subject><subject>肝门静脉高压</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkcuP0zAQhyMEYsvCnROyEOKW4lfi5IK0WvGSVtoLnC3XmTQuiZ21nZb975moFY_THDzz-Zv5FcVrRrdCyebD6bDfHhnbOi62olL0SbHhnLUlbyR9WmwYpapsBVdXxYuUDpRyISr-vLhiVVtzodSm8Pe_XGeyOwJJOUJKxHkyh5jNSIbHGWIGn1zwpfPdYqEj0eRETi4PZDYxO7uMJhKY5sEkl0jwxLscnSUBuUCM70iOxgKZAJHpZfGsxwKvLvW6-PH50_fbr-Xd_Zdvtzd3pZUVzWXTqkZ2tGGcUqZqpaTgFvqaMwW7qrbK7qzhuGXdCF61RqrW1MJ2IGUjhZDiuvh45s7LboLOgkeLUc_RTSY-6mCc_v_Fu0Hvw1FLsd5GIODdGXAyvjd-rw9hiR6VNd4crSou0Azb3l_-ieFhgZT15JKFcTQewpJ0rVpUYiuPnhttDClF6P-4MKrXLFeuxiw1ZqnXLHHkzb87_B24hIcNby_MIfj9g0PLnbE_ezcCNjV1xTHw30p5qJk</recordid><startdate>20050621</startdate><enddate>20050621</enddate><creator>Izzet, Titiz</creator><creator>Osman, Krand</creator><creator>Ethem, Unal</creator><creator>Nihat, Yavuz</creator><creator>Ramazan, Kusaslan</creator><creator>Mustafa, Dogan</creator><creator>Hafize, Uzun</creator><creator>Riza, Kiziler Ali</creator><creator>Birsen, Aydemir</creator><creator>Habibe, Genc</creator><creator>Seval, Aydin</creator><creator>Gonul, Simsek</creator><general>Department of Surgery, Haydarpasa Numune Training and Research Hospital, Istanbul,Turkey%Department of Surgery, Cerrahpasa Faculty of Medicine, Istanbul University,Istanbul, Turkey%Department of Biochemistry, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey%Department of Biophysics, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul,Turkey%Department of Physiology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey</general><general>Baishideng Publishing Group Inc</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope><scope>5PM</scope></search><sort><creationdate>20050621</creationdate><title>Oxidative stress in portal hypertension-induced rats with particular emphasis on nitric oxide and trace metals</title><author>Izzet, Titiz ; 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METHODS: Cirrhosis was induced by partial portal vein ligation (PVL) in Wistar rats. The lipid peroxidation marker (malondialdehyde, MDA), antioxidant defense enzymes including superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), and agents known to have antioxidant features including nitric oxide (NO), zinc (Zn), copper (Cu) were determined both in serum and in liver tissue at 4 wk after surgery in PVL and sham-operated rats. Portal pressure of all experimental animals was measured. MDA was detected by thiobarbituric acid reactivity assay.SOD activity was determined by inhibition of nitroblue tetrazolium reduction with xanthine/xanthine oxidase usedas a superoxide generator. CAT activity was determined by the breakdown of hydrogen peroxide. GSH concentrations were measured by using metaphosphoric acid for protein precipitation and 5'-5'-dithio-bis-2-nitrobenzoic acid for color development. NO was detected by the Griess method after reduction of nitrate to nitrite with nitrate reductase, and the concentrations of Zn and Cu were measured by a Shimadzu 680 AA atomic absorption spectrometer. Histopathological confirmation was done under lightmicroscope. Statistical analyses were done by Student's t-test, and significance of the difference was tested by the unpaired Mann-Whitney test. P<0.05 was considered statistically significant.RESULTS: Histopathological studies confirmed PVLinduced cirrhotic changes. There was a statistically significant difference in portal pressure between PVL andcont rol groups (P<0.001). The results showed significant increases in the levels of MDA and NO in both tissue and serum (P<0.05 and P<0.001, respectively in tissue; P<0.001 for each in serum), and Zn only in tissue (P<0.001)in rats with PVL compared with sham-operated rats. Besides, PVL rats exhibited reduced plasma and tissue GSH, CAT, SOD (P<0.001 for each). Serum and tissue Cuconcentration did not change. CONCLUSION: Our findings suggest that PVL in rats induces important biochemical and molecular changes related to oxidative stress in the liver.]]></abstract><cop>United States</cop><pub>Department of Surgery, Haydarpasa Numune Training and Research Hospital, Istanbul,Turkey%Department of Surgery, Cerrahpasa Faculty of Medicine, Istanbul University,Istanbul, Turkey%Department of Biochemistry, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey%Department of Biophysics, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul,Turkey%Department of Physiology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey</pub><pmid>15962377</pmid><doi>10.3748/wjg.v11.i23.3570</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1007-9327 |
| ispartof | World journal of gastroenterology : WJG, 2005-06, Vol.11 (23), p.3570-3573 |
| issn | 1007-9327 2219-2840 |
| language | eng |
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| source | MEDLINE; PubMed Central; Alma/SFX Local Collection |
| subjects | Animals Antioxidants - pharmacology Brief Reports Copper - blood Copper - metabolism Hypertension, Portal - physiopathology Lipid Peroxidation Liver - metabolism Liver - physiopathology Male Nitric Oxide - blood Nitric Oxide - metabolism Oxidative Stress Portal Vein - pathology Rats Rats, Wistar Trace Elements - blood Trace Elements - metabolism Zinc - blood Zinc - metabolism 一氧化氮 动物实验 氧化损伤 肝门静脉高压 |
| title | Oxidative stress in portal hypertension-induced rats with particular emphasis on nitric oxide and trace metals |
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