Differential impact of adenosine nucleotides released by osteocytes on breast cancer growth and bone metastasis

Extracellular ATP has been shown to either inhibit or promote cancer growth and migration; however, the mechanism underlying this discrepancy remained elusive. Here we demonstrate the divergent roles of ATP and adenosine released by bone osteocytes on breast cancers. We showed that conditioned media...

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Veröffentlicht in:	Oncogene 2015-04, Vol.34 (14), p.1831-1842
Hauptverfasser:	Zhou, J Z, Riquelme, M A, Gao, X, Ellies, L G, Sun, L Z, Jiang, J X
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/1 14/34 14/63 59 59/5 631/67/322 Adenosine Adenosine - metabolism Adenosine triphosphatase Adenosine triphosphate Adenosine Triphosphate - analogs & derivatives Adenosine Triphosphate - metabolism Adenosine Triphosphate - pharmacology Alendronate - pharmacology Alendronic acid Animals Apoptosis Apyrase Apyrase - pharmacology Bisphosphonates Bone cancer Bone Density Conservation Agents - pharmacology Bone growth Bone Neoplasms - secondary Bones Breast cancer Breast Neoplasms - genetics Breast Neoplasms - pathology Carcinoma Cell adhesion & migration Cell Biology Cell Line, Tumor Cell migration Cell Movement - drug effects Cell Proliferation Complications and side effects Development and progression Female Genetic aspects Health aspects Human Genetics Humans Internal Medicine Mammary gland Medicine Medicine & Public Health Metastases Metastasis Mice Mice, Inbred C57BL Mice, Nude Neoplasm Transplantation Nucleotides Oncology original-article Osteocytes Osteocytes - metabolism Purine P2X receptors Receptor, Adenosine A2A - genetics Receptor, Adenosine A2A - metabolism Receptors, Purinergic P2X - genetics Receptors, Purinergic P2X - metabolism RNA Interference RNA, Small Interfering Signal Transduction siRNA Transplantation, Heterologous Xenografts
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