Retinal damage and vision loss in African American multiple sclerosis patients
Objective To determine whether African American (AA) multiple sclerosis (MS) patients exhibit more retinal damage and visual impairment compared to Caucasian American (CA) MS patients. Methods A total of 687 MS patients (81 AAs) and 110 healthy control (HC) subjects (14 AAs) were recruited at 3 acad...
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| Veröffentlicht in: | Annals of neurology 2015-02, Vol.77 (2), p.228-236 |
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| container_title | Annals of neurology |
| container_volume | 77 |
| creator | Kimbrough, Dorlan J. Sotirchos, Elias S. Wilson, James A. Al-Louzi, Omar Conger, Amy Conger, Darrel Frohman, Teresa C. Saidha, Shiv Green, Ari J. Frohman, Elliot M. Balcer, Laura J. Calabresi, Peter A. |
| description | Objective
To determine whether African American (AA) multiple sclerosis (MS) patients exhibit more retinal damage and visual impairment compared to Caucasian American (CA) MS patients.
Methods
A total of 687 MS patients (81 AAs) and 110 healthy control (HC) subjects (14 AAs) were recruited at 3 academic hospitals between 2008 and 2012. Using mixed effects regression models, we compared high‐ and low‐contrast visual acuity (HCVA and LCVA) and high‐definition spectral domain optical coherence tomography measures of retinal architecture between MS patients of self‐identified AA and CA ancestry.
Results
In HCs, baseline peripapillary retinal nerve fiber layer (RNFL) thickness was 6.1µm greater in AAs (p = 0.047), whereas ganglion cell/inner plexiform layer (GCIP) thickness did not differ by race. In MS patients, baseline RNFL did not differ by race, and GCIP was 3.98µm thinner in AAs (p = 0.004). AAs had faster RNFL and GCIP thinning rates compared to CAs (p = 0.004 and p = 0.046, respectively). AA MS patients had lower baseline HCVA (p = 0.02) and worse LCVA per year of disease duration (p = 0.039). Among patients with an acute optic neuritis (AON) history, AAs had greater loss of HCVA than CA patients (p = 0.012).
Interpretation
This multicenter investigation provides objective evidence that AA MS patients exhibit accelerated retinal damage compared to CA MS patients. Self‐identified AA ancestry is associated with worse MS‐related visual disability, particularly in the context of an AON history, suggesting a more aggressive inflammatory disease course among AA MS patients or a subpopulation therein. Ann Neurol 2015;77:228–236 |
| doi_str_mv | 10.1002/ana.24308 |
| format | Article |
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To determine whether African American (AA) multiple sclerosis (MS) patients exhibit more retinal damage and visual impairment compared to Caucasian American (CA) MS patients.
Methods
A total of 687 MS patients (81 AAs) and 110 healthy control (HC) subjects (14 AAs) were recruited at 3 academic hospitals between 2008 and 2012. Using mixed effects regression models, we compared high‐ and low‐contrast visual acuity (HCVA and LCVA) and high‐definition spectral domain optical coherence tomography measures of retinal architecture between MS patients of self‐identified AA and CA ancestry.
Results
In HCs, baseline peripapillary retinal nerve fiber layer (RNFL) thickness was 6.1µm greater in AAs (p = 0.047), whereas ganglion cell/inner plexiform layer (GCIP) thickness did not differ by race. In MS patients, baseline RNFL did not differ by race, and GCIP was 3.98µm thinner in AAs (p = 0.004). AAs had faster RNFL and GCIP thinning rates compared to CAs (p = 0.004 and p = 0.046, respectively). AA MS patients had lower baseline HCVA (p = 0.02) and worse LCVA per year of disease duration (p = 0.039). Among patients with an acute optic neuritis (AON) history, AAs had greater loss of HCVA than CA patients (p = 0.012).
Interpretation
This multicenter investigation provides objective evidence that AA MS patients exhibit accelerated retinal damage compared to CA MS patients. Self‐identified AA ancestry is associated with worse MS‐related visual disability, particularly in the context of an AON history, suggesting a more aggressive inflammatory disease course among AA MS patients or a subpopulation therein. Ann Neurol 2015;77:228–236</description><identifier>ISSN: 0364-5134</identifier><identifier>EISSN: 1531-8249</identifier><identifier>DOI: 10.1002/ana.24308</identifier><identifier>PMID: 25382184</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; African Americans - ethnology ; Aged ; European Continental Ancestry Group - ethnology ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Multiple Sclerosis - diagnosis ; Multiple Sclerosis - ethnology ; Retina - pathology ; Vision, Low - diagnosis ; Vision, Low - ethnology ; Young Adult</subject><ispartof>Annals of neurology, 2015-02, Vol.77 (2), p.228-236</ispartof><rights>2014 American Neurological Association</rights><rights>2014 American Neurological Association.</rights><rights>2015 American Neurological Association</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fana.24308$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fana.24308$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25382184$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kimbrough, Dorlan J.</creatorcontrib><creatorcontrib>Sotirchos, Elias S.</creatorcontrib><creatorcontrib>Wilson, James A.</creatorcontrib><creatorcontrib>Al-Louzi, Omar</creatorcontrib><creatorcontrib>Conger, Amy</creatorcontrib><creatorcontrib>Conger, Darrel</creatorcontrib><creatorcontrib>Frohman, Teresa C.</creatorcontrib><creatorcontrib>Saidha, Shiv</creatorcontrib><creatorcontrib>Green, Ari J.</creatorcontrib><creatorcontrib>Frohman, Elliot M.</creatorcontrib><creatorcontrib>Balcer, Laura J.</creatorcontrib><creatorcontrib>Calabresi, Peter A.</creatorcontrib><title>Retinal damage and vision loss in African American multiple sclerosis patients</title><title>Annals of neurology</title><addtitle>Ann Neurol</addtitle><description>Objective
To determine whether African American (AA) multiple sclerosis (MS) patients exhibit more retinal damage and visual impairment compared to Caucasian American (CA) MS patients.
Methods
A total of 687 MS patients (81 AAs) and 110 healthy control (HC) subjects (14 AAs) were recruited at 3 academic hospitals between 2008 and 2012. Using mixed effects regression models, we compared high‐ and low‐contrast visual acuity (HCVA and LCVA) and high‐definition spectral domain optical coherence tomography measures of retinal architecture between MS patients of self‐identified AA and CA ancestry.
Results
In HCs, baseline peripapillary retinal nerve fiber layer (RNFL) thickness was 6.1µm greater in AAs (p = 0.047), whereas ganglion cell/inner plexiform layer (GCIP) thickness did not differ by race. In MS patients, baseline RNFL did not differ by race, and GCIP was 3.98µm thinner in AAs (p = 0.004). AAs had faster RNFL and GCIP thinning rates compared to CAs (p = 0.004 and p = 0.046, respectively). AA MS patients had lower baseline HCVA (p = 0.02) and worse LCVA per year of disease duration (p = 0.039). Among patients with an acute optic neuritis (AON) history, AAs had greater loss of HCVA than CA patients (p = 0.012).
Interpretation
This multicenter investigation provides objective evidence that AA MS patients exhibit accelerated retinal damage compared to CA MS patients. Self‐identified AA ancestry is associated with worse MS‐related visual disability, particularly in the context of an AON history, suggesting a more aggressive inflammatory disease course among AA MS patients or a subpopulation therein. Ann Neurol 2015;77:228–236</description><subject>Adolescent</subject><subject>Adult</subject><subject>African Americans - ethnology</subject><subject>Aged</subject><subject>European Continental Ancestry Group - ethnology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multiple Sclerosis - diagnosis</subject><subject>Multiple Sclerosis - ethnology</subject><subject>Retina - pathology</subject><subject>Vision, Low - diagnosis</subject><subject>Vision, Low - ethnology</subject><subject>Young Adult</subject><issn>0364-5134</issn><issn>1531-8249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1P3DAQhi1EBVvKgT-AIvXSS2DGH3F8qbRaFdoKbaV-iKM1ib1g6iTbOKHl3zfs0lXbE6cZaZ73ndG8jJ0gnCEAP6eWzrgUUO6xGSqBecml2WczEIXMFQp5yF6mdAcApkA4YIdciZJjKWds-dkPoaWYOWroxmfUuuw-pNC1WexSykKbzVd9qGmqjd82zRiHsI4-S3X0fZdCytY0BN8O6RV7saKY_PFTPWLfLt59XbzPrz5dfljMr_KgdFHmHrgzstLaOawkSQDlvPNYCe_0imtFZEoh0aja18IQGlcDX2GFCgokI47Y263veqwa7-ppd0_RrvvQUP9gOwr230kbbu1Nd2-lQKVlMRm8eTLoux-jT4NtQqp9jNT6bkwWiwIkSKn5M1DFpeTKyAl9_R9614399N4NBUIY5I-7T_8-fnf1n1Qm4HwL_AzRP-zmCPYxbjvFbTdx2_lyvmkmRb5VhDT4XzsF9d9toYVW9np5ab9c64X5eIFWiN9rTKtH</recordid><startdate>201502</startdate><enddate>201502</enddate><creator>Kimbrough, Dorlan J.</creator><creator>Sotirchos, Elias S.</creator><creator>Wilson, James A.</creator><creator>Al-Louzi, Omar</creator><creator>Conger, Amy</creator><creator>Conger, Darrel</creator><creator>Frohman, Teresa C.</creator><creator>Saidha, Shiv</creator><creator>Green, Ari J.</creator><creator>Frohman, Elliot M.</creator><creator>Balcer, Laura J.</creator><creator>Calabresi, Peter A.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201502</creationdate><title>Retinal damage and vision loss in African American multiple sclerosis patients</title><author>Kimbrough, Dorlan J. ; Sotirchos, Elias S. ; Wilson, James A. ; Al-Louzi, Omar ; Conger, Amy ; Conger, Darrel ; Frohman, Teresa C. ; Saidha, Shiv ; Green, Ari J. ; Frohman, Elliot M. ; Balcer, Laura J. ; Calabresi, Peter A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i5768-e02d94b77dd1b4a4005dede1b3ed7f275aa9834195cec39a19dc02f1b15061a93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>African Americans - ethnology</topic><topic>Aged</topic><topic>European Continental Ancestry Group - ethnology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multiple Sclerosis - diagnosis</topic><topic>Multiple Sclerosis - ethnology</topic><topic>Retina - pathology</topic><topic>Vision, Low - diagnosis</topic><topic>Vision, Low - ethnology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kimbrough, Dorlan J.</creatorcontrib><creatorcontrib>Sotirchos, Elias S.</creatorcontrib><creatorcontrib>Wilson, James A.</creatorcontrib><creatorcontrib>Al-Louzi, Omar</creatorcontrib><creatorcontrib>Conger, Amy</creatorcontrib><creatorcontrib>Conger, Darrel</creatorcontrib><creatorcontrib>Frohman, Teresa C.</creatorcontrib><creatorcontrib>Saidha, Shiv</creatorcontrib><creatorcontrib>Green, Ari J.</creatorcontrib><creatorcontrib>Frohman, Elliot M.</creatorcontrib><creatorcontrib>Balcer, Laura J.</creatorcontrib><creatorcontrib>Calabresi, Peter A.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Annals of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kimbrough, Dorlan J.</au><au>Sotirchos, Elias S.</au><au>Wilson, James A.</au><au>Al-Louzi, Omar</au><au>Conger, Amy</au><au>Conger, Darrel</au><au>Frohman, Teresa C.</au><au>Saidha, Shiv</au><au>Green, Ari J.</au><au>Frohman, Elliot M.</au><au>Balcer, Laura J.</au><au>Calabresi, Peter A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Retinal damage and vision loss in African American multiple sclerosis patients</atitle><jtitle>Annals of neurology</jtitle><addtitle>Ann Neurol</addtitle><date>2015-02</date><risdate>2015</risdate><volume>77</volume><issue>2</issue><spage>228</spage><epage>236</epage><pages>228-236</pages><issn>0364-5134</issn><eissn>1531-8249</eissn><abstract>Objective
To determine whether African American (AA) multiple sclerosis (MS) patients exhibit more retinal damage and visual impairment compared to Caucasian American (CA) MS patients.
Methods
A total of 687 MS patients (81 AAs) and 110 healthy control (HC) subjects (14 AAs) were recruited at 3 academic hospitals between 2008 and 2012. Using mixed effects regression models, we compared high‐ and low‐contrast visual acuity (HCVA and LCVA) and high‐definition spectral domain optical coherence tomography measures of retinal architecture between MS patients of self‐identified AA and CA ancestry.
Results
In HCs, baseline peripapillary retinal nerve fiber layer (RNFL) thickness was 6.1µm greater in AAs (p = 0.047), whereas ganglion cell/inner plexiform layer (GCIP) thickness did not differ by race. In MS patients, baseline RNFL did not differ by race, and GCIP was 3.98µm thinner in AAs (p = 0.004). AAs had faster RNFL and GCIP thinning rates compared to CAs (p = 0.004 and p = 0.046, respectively). AA MS patients had lower baseline HCVA (p = 0.02) and worse LCVA per year of disease duration (p = 0.039). Among patients with an acute optic neuritis (AON) history, AAs had greater loss of HCVA than CA patients (p = 0.012).
Interpretation
This multicenter investigation provides objective evidence that AA MS patients exhibit accelerated retinal damage compared to CA MS patients. Self‐identified AA ancestry is associated with worse MS‐related visual disability, particularly in the context of an AON history, suggesting a more aggressive inflammatory disease course among AA MS patients or a subpopulation therein. Ann Neurol 2015;77:228–236</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>25382184</pmid><doi>10.1002/ana.24308</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Annals of neurology, 2015-02, Vol.77 (2), p.228-236 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescent Adult African Americans - ethnology Aged European Continental Ancestry Group - ethnology Female Follow-Up Studies Humans Male Middle Aged Multiple Sclerosis - diagnosis Multiple Sclerosis - ethnology Retina - pathology Vision, Low - diagnosis Vision, Low - ethnology Young Adult |
| title | Retinal damage and vision loss in African American multiple sclerosis patients |
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