Idiopathic scoliosis and the vestibular system
Purpose Despite its high prevalence, the etiology underlying idiopathic scoliosis remains unclear. Although initial scrutiny has focused on genetic, biochemical, biomechanical, nutritional and congenital causes, there is growing evidence that aberrations in the vestibular system may play a role in t...
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| Veröffentlicht in: | European spine journal 2015-02, Vol.24 (2), p.227-233 |
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| container_title | European spine journal |
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| creator | Hawasli, Ammar H. Hullar, Timothy E. Dorward, Ian G. |
| description | Purpose
Despite its high prevalence, the etiology underlying idiopathic scoliosis remains unclear. Although initial scrutiny has focused on genetic, biochemical, biomechanical, nutritional and congenital causes, there is growing evidence that aberrations in the vestibular system may play a role in the etiology of scoliosis. In this article, we discuss putative mechanisms for adolescent idiopathic scoliosis and review the current evidence supporting a role for the vestibular system in adolescent idiopathic scoliosis.
Methods
A comprehensive search of the English literature was performed using PubMed (
http://www.ncbi.nlm.nih.gov/pubmed
). Research articles studying interactions between adolescent idiopathic scoliosis and the vestibular system were selected and evaluated for inclusion in a literature review.
Results
Eighteen manuscripts of level 3–4 clinical evidence to support an association between adolescent idiopathic scoliosis (AIS) and dysfunction of the vestibular system were identified. These studies include data from physiologic and morphologic studies in humans. Clinical data are supported by animal model studies to suggest a causative link between the vestibular system and AIS.
Conclusions
Clinical data and a limited number of animal model studies suggest a causative role of the vestibular system in AIS, although this association has not been reproduced in all studies. |
| doi_str_mv | 10.1007/s00586-014-3701-4 |
| format | Article |
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Despite its high prevalence, the etiology underlying idiopathic scoliosis remains unclear. Although initial scrutiny has focused on genetic, biochemical, biomechanical, nutritional and congenital causes, there is growing evidence that aberrations in the vestibular system may play a role in the etiology of scoliosis. In this article, we discuss putative mechanisms for adolescent idiopathic scoliosis and review the current evidence supporting a role for the vestibular system in adolescent idiopathic scoliosis.
Methods
A comprehensive search of the English literature was performed using PubMed (
http://www.ncbi.nlm.nih.gov/pubmed
). Research articles studying interactions between adolescent idiopathic scoliosis and the vestibular system were selected and evaluated for inclusion in a literature review.
Results
Eighteen manuscripts of level 3–4 clinical evidence to support an association between adolescent idiopathic scoliosis (AIS) and dysfunction of the vestibular system were identified. These studies include data from physiologic and morphologic studies in humans. Clinical data are supported by animal model studies to suggest a causative link between the vestibular system and AIS.
Conclusions
Clinical data and a limited number of animal model studies suggest a causative role of the vestibular system in AIS, although this association has not been reproduced in all studies.</description><identifier>ISSN: 0940-6719</identifier><identifier>EISSN: 1432-0932</identifier><identifier>DOI: 10.1007/s00586-014-3701-4</identifier><identifier>PMID: 25430569</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adolescent ; Animals ; Child ; Humans ; Magnetic Resonance Imaging ; Medicine ; Medicine & Public Health ; Neurosurgery ; Review Article ; Scoliosis - etiology ; Scoliosis - physiopathology ; Surgical Orthopedics ; Vestibule, Labyrinth - physiopathology</subject><ispartof>European spine journal, 2015-02, Vol.24 (2), p.227-233</ispartof><rights>Springer-Verlag Berlin Heidelberg 2014</rights><rights>Springer-Verlag Berlin Heidelberg 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c573t-b806657b2e08d01a96eee7b541c4b6a1d8ccf6aa444148dae0c10c77752155ab3</citedby><cites>FETCH-LOGICAL-c573t-b806657b2e08d01a96eee7b541c4b6a1d8ccf6aa444148dae0c10c77752155ab3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00586-014-3701-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00586-014-3701-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25430569$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hawasli, Ammar H.</creatorcontrib><creatorcontrib>Hullar, Timothy E.</creatorcontrib><creatorcontrib>Dorward, Ian G.</creatorcontrib><title>Idiopathic scoliosis and the vestibular system</title><title>European spine journal</title><addtitle>Eur Spine J</addtitle><addtitle>Eur Spine J</addtitle><description>Purpose
Despite its high prevalence, the etiology underlying idiopathic scoliosis remains unclear. Although initial scrutiny has focused on genetic, biochemical, biomechanical, nutritional and congenital causes, there is growing evidence that aberrations in the vestibular system may play a role in the etiology of scoliosis. In this article, we discuss putative mechanisms for adolescent idiopathic scoliosis and review the current evidence supporting a role for the vestibular system in adolescent idiopathic scoliosis.
Methods
A comprehensive search of the English literature was performed using PubMed (
http://www.ncbi.nlm.nih.gov/pubmed
). Research articles studying interactions between adolescent idiopathic scoliosis and the vestibular system were selected and evaluated for inclusion in a literature review.
Results
Eighteen manuscripts of level 3–4 clinical evidence to support an association between adolescent idiopathic scoliosis (AIS) and dysfunction of the vestibular system were identified. These studies include data from physiologic and morphologic studies in humans. Clinical data are supported by animal model studies to suggest a causative link between the vestibular system and AIS.
Conclusions
Clinical data and a limited number of animal model studies suggest a causative role of the vestibular system in AIS, although this association has not been reproduced in all studies.</description><subject>Adolescent</subject><subject>Animals</subject><subject>Child</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurosurgery</subject><subject>Review Article</subject><subject>Scoliosis - etiology</subject><subject>Scoliosis - physiopathology</subject><subject>Surgical Orthopedics</subject><subject>Vestibule, Labyrinth - physiopathology</subject><issn>0940-6719</issn><issn>1432-0932</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkU1LAzEURYMotlZ_gBsZcONm9L2ZfMxsBCl-geBG1yGTSduU6aQmM0L_vSmtpQqCqyzeyc27OYScI1wjgLgJAKzgKSBNcwGY0gMyRJpnKZR5dkiGUFJIucByQE5CmAMgK4Efk0HGaA6Ml0Ny_Vxbt1TdzOokaNdYF2xIVFsn3cwknyZ0tuob5ZOwCp1ZnJKjiWqCOdueI_L-cP82fkpfXh-fx3cvqWYi79KqAM6ZqDIDRQ2oSm6MERWjqGnFFdaF1hOuFKUUaVErAxpBCyFYhoypKh-R203usq8Wptam7bxq5NLbhfIr6ZSVPyetncmp-5Q0x9irjAFX2wDvPvpYQy5s0KZpVGtcHyRyDjSjWBT_QFlGKQdco5e_0LnrfRt_Yk1BXmD0ECncUNq7ELyZ7PZGkGtxciNORnFyLS5uPSIX-4V3N75NRSDbACGO2qnxe0__mfoF7b-iVw</recordid><startdate>20150201</startdate><enddate>20150201</enddate><creator>Hawasli, Ammar H.</creator><creator>Hullar, Timothy E.</creator><creator>Dorward, Ian G.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150201</creationdate><title>Idiopathic scoliosis and the vestibular system</title><author>Hawasli, Ammar H. ; Hullar, Timothy E. ; Dorward, Ian G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c573t-b806657b2e08d01a96eee7b541c4b6a1d8ccf6aa444148dae0c10c77752155ab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Animals</topic><topic>Child</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurosurgery</topic><topic>Review Article</topic><topic>Scoliosis - etiology</topic><topic>Scoliosis - physiopathology</topic><topic>Surgical Orthopedics</topic><topic>Vestibule, Labyrinth - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hawasli, Ammar H.</creatorcontrib><creatorcontrib>Hullar, Timothy E.</creatorcontrib><creatorcontrib>Dorward, Ian G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European spine journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hawasli, Ammar H.</au><au>Hullar, Timothy E.</au><au>Dorward, Ian G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Idiopathic scoliosis and the vestibular system</atitle><jtitle>European spine journal</jtitle><stitle>Eur Spine J</stitle><addtitle>Eur Spine J</addtitle><date>2015-02-01</date><risdate>2015</risdate><volume>24</volume><issue>2</issue><spage>227</spage><epage>233</epage><pages>227-233</pages><issn>0940-6719</issn><eissn>1432-0932</eissn><abstract>Purpose
Despite its high prevalence, the etiology underlying idiopathic scoliosis remains unclear. Although initial scrutiny has focused on genetic, biochemical, biomechanical, nutritional and congenital causes, there is growing evidence that aberrations in the vestibular system may play a role in the etiology of scoliosis. In this article, we discuss putative mechanisms for adolescent idiopathic scoliosis and review the current evidence supporting a role for the vestibular system in adolescent idiopathic scoliosis.
Methods
A comprehensive search of the English literature was performed using PubMed (
http://www.ncbi.nlm.nih.gov/pubmed
). Research articles studying interactions between adolescent idiopathic scoliosis and the vestibular system were selected and evaluated for inclusion in a literature review.
Results
Eighteen manuscripts of level 3–4 clinical evidence to support an association between adolescent idiopathic scoliosis (AIS) and dysfunction of the vestibular system were identified. These studies include data from physiologic and morphologic studies in humans. Clinical data are supported by animal model studies to suggest a causative link between the vestibular system and AIS.
Conclusions
Clinical data and a limited number of animal model studies suggest a causative role of the vestibular system in AIS, although this association has not been reproduced in all studies.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>25430569</pmid><doi>10.1007/s00586-014-3701-4</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0940-6719 |
| ispartof | European spine journal, 2015-02, Vol.24 (2), p.227-233 |
| issn | 0940-6719 1432-0932 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adolescent Animals Child Humans Magnetic Resonance Imaging Medicine Medicine & Public Health Neurosurgery Review Article Scoliosis - etiology Scoliosis - physiopathology Surgical Orthopedics Vestibule, Labyrinth - physiopathology |
| title | Idiopathic scoliosis and the vestibular system |
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