Ribosomal protein S19-binding domain provides insights into hantavirus nucleocapsid protein-mediated translation initiation mechanism

The hantaviral zoonotic diseases pose a significant threat to human health due to the lack of potential antiviral therapeutics or a vaccine against hantaviruses. N (Sin Nombre hantavirus nucleocapsid protein) augments mRNA translation. N binds to both the mRNA 5' cap and 40S ribosomal subunit v...

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Veröffentlicht in:	Biochemical journal 2014-11, Vol.464 (1), p.109-121
Hauptverfasser:	Ganaie, Safder S, Haque, Absarul, Cheng, Erdong, Bonny, Tania S, Salim, Nilshad N, Mir, Mohammad A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Binding Sites - physiology Hantavirus - physiology HeLa Cells Humans Molecular Sequence Data Nucleocapsid Proteins - physiology Peptide Chain Initiation, Translational - physiology Ribosomal Proteins - genetics Ribosomal Proteins - metabolism
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