IKKα is required for the homeostasis of regulatory T cells and for the expansion of both regulatory and effector CD4 T cells

ABSTRACT It was reported that TNF receptor type II signaling, which has the capacity to stimulate CD4+ fork‐head box P3+ (Foxp3+) regulatory T cells (Tregs), activated the noncanonical NF‐κB pathway in an IKKα‐dependent manner. Therefore, we studied the role of IKKα in the homeostasis of Treg popula...

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Veröffentlicht in:The FASEB journal 2015-02, Vol.29 (2), p.443-454
Hauptverfasser: Chen, Xin, Willette‐Brown, Jami, Wu, Xueqiang, Hu, Ya, Howard, O. M. Zack, Hu, Yinling, Oppenheim, Joost J.
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Sprache:eng
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