The rise of regulatory RNA
Discoveries over the past decade portend a paradigm shift in molecular biology; evidence suggests that RNA is not only functional as a messenger between DNA and protein but also involved in the regulation of genome organization and gene expression. This Timeline article surveys the emergence of the...
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| Veröffentlicht in: | Nature reviews. Genetics 2014-06, Vol.15 (6), p.423-437 |
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| container_title | Nature reviews. Genetics |
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| creator | Morris, Kevin V. Mattick, John S. |
| description | Discoveries over the past decade portend a paradigm shift in molecular biology; evidence suggests that RNA is not only functional as a messenger between DNA and protein but also involved in the regulation of genome organization and gene expression. This Timeline article surveys the emergence of the previously unsuspected world of regulatory RNA from a historical perspective.
Discoveries over the past decade portend a paradigm shift in molecular biology. Evidence suggests that RNA is not only functional as a messenger between DNA and protein but also involved in the regulation of genome organization and gene expression, which is increasingly elaborate in complex organisms. Regulatory RNA seems to operate at many levels; in particular, it plays an important part in the epigenetic processes that control differentiation and development. These discoveries suggest a central role for RNA in human evolution and ontogeny. Here, we review the emergence of the previously unsuspected world of regulatory RNA from a historical perspective. |
| doi_str_mv | 10.1038/nrg3722 |
| format | Article |
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Discoveries over the past decade portend a paradigm shift in molecular biology. Evidence suggests that RNA is not only functional as a messenger between DNA and protein but also involved in the regulation of genome organization and gene expression, which is increasingly elaborate in complex organisms. Regulatory RNA seems to operate at many levels; in particular, it plays an important part in the epigenetic processes that control differentiation and development. These discoveries suggest a central role for RNA in human evolution and ontogeny. Here, we review the emergence of the previously unsuspected world of regulatory RNA from a historical perspective.</description><identifier>ISSN: 1471-0056</identifier><identifier>EISSN: 1471-0064</identifier><identifier>DOI: 10.1038/nrg3722</identifier><identifier>PMID: 24776770</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/337/384 ; 631/337/384/2053 ; 631/337/384/2568 ; 706/648/236 ; Agriculture ; Animal Genetics and Genomics ; Animals ; Biomedicine ; Cancer Research ; Cytology ; Developmental genetics ; DNA methylation ; Enzymes ; Epigenesis, Genetic - physiology ; Evolution, Molecular ; Gene expression ; Gene Function ; Genome, Human - physiology ; Genomes ; History ; Human Genetics ; Humans ; Hypotheses ; MicroRNAs ; Molecular biology ; Mutation ; Physiological aspects ; Polypeptides ; Proteins ; RNA ; RNA, Untranslated - physiology ; timeline ; Transfer RNA</subject><ispartof>Nature reviews. Genetics, 2014-06, Vol.15 (6), p.423-437</ispartof><rights>Springer Nature Limited 2014</rights><rights>COPYRIGHT 2014 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jun 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c595t-c9ffba6718cc0effbd9ad60a1958b6acdc8b95c528e5124ffda6527f657607203</citedby><cites>FETCH-LOGICAL-c595t-c9ffba6718cc0effbd9ad60a1958b6acdc8b95c528e5124ffda6527f657607203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/nrg3722$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/nrg3722$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24776770$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Morris, Kevin V.</creatorcontrib><creatorcontrib>Mattick, John S.</creatorcontrib><title>The rise of regulatory RNA</title><title>Nature reviews. Genetics</title><addtitle>Nat Rev Genet</addtitle><addtitle>Nat Rev Genet</addtitle><description>Discoveries over the past decade portend a paradigm shift in molecular biology; evidence suggests that RNA is not only functional as a messenger between DNA and protein but also involved in the regulation of genome organization and gene expression. This Timeline article surveys the emergence of the previously unsuspected world of regulatory RNA from a historical perspective.
Discoveries over the past decade portend a paradigm shift in molecular biology. Evidence suggests that RNA is not only functional as a messenger between DNA and protein but also involved in the regulation of genome organization and gene expression, which is increasingly elaborate in complex organisms. Regulatory RNA seems to operate at many levels; in particular, it plays an important part in the epigenetic processes that control differentiation and development. These discoveries suggest a central role for RNA in human evolution and ontogeny. Here, we review the emergence of the previously unsuspected world of regulatory RNA from a historical perspective.</description><subject>631/337/384</subject><subject>631/337/384/2053</subject><subject>631/337/384/2568</subject><subject>706/648/236</subject><subject>Agriculture</subject><subject>Animal Genetics and Genomics</subject><subject>Animals</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Cytology</subject><subject>Developmental genetics</subject><subject>DNA methylation</subject><subject>Enzymes</subject><subject>Epigenesis, Genetic - physiology</subject><subject>Evolution, Molecular</subject><subject>Gene expression</subject><subject>Gene Function</subject><subject>Genome, Human - physiology</subject><subject>Genomes</subject><subject>History</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Hypotheses</subject><subject>MicroRNAs</subject><subject>Molecular biology</subject><subject>Mutation</subject><subject>Physiological aspects</subject><subject>Polypeptides</subject><subject>Proteins</subject><subject>RNA</subject><subject>RNA, Untranslated - physiology</subject><subject>timeline</subject><subject>Transfer RNA</subject><issn>1471-0056</issn><issn>1471-0064</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNksuLFDEQxoMo7jqKdw8yIPg4zJpK59F9EYbFx8KisK7nkElXerL0JGvSLe5_b8Ydx-nFg-SQIvWrj-LLR8hToCdAq_ptSF2lGLtHjoErWFAq-f19LeQReZTzFaUgQVUPyRHjSkml6DF5drnGefIZ59HNE3Zjb4aYbuYXn5ePyQNn-oxPdveMfPvw_vL00-L8y8ez0-X5wopGDAvbOLcyUkFtLcVSt41pJTXQiHoljW1tvWqEFaxGAYw71xopmHJSKEkVo9WMvLvVvR5XG2wthiGZXl8nvzHpRkfj9bQT_Fp38YfmFXAAKAKvdwIpfh8xD3rjs8W-NwHjmDUITlnFBDT_gTKhFKhaFPTFHfQqjikUJzRIUSvJ-W_BHdWZHrUPLpYV7VZULytFacW2ls_IyT-oclrceBsDOl_eJwNvJgOFGfDn0JkxZ3329WLKvjxg12j6YZ1jPw4-hjwFX92CNsWcE7q9x0D1NkZ6F6NCPj_8kj33Jzd_fcylFTpMB-bc0foF9RvKZw</recordid><startdate>20140601</startdate><enddate>20140601</enddate><creator>Morris, Kevin V.</creator><creator>Mattick, John S.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7QP</scope><scope>7QR</scope><scope>7RV</scope><scope>7TK</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140601</creationdate><title>The rise of regulatory RNA</title><author>Morris, Kevin V. ; Mattick, John S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c595t-c9ffba6718cc0effbd9ad60a1958b6acdc8b95c528e5124ffda6527f657607203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>631/337/384</topic><topic>631/337/384/2053</topic><topic>631/337/384/2568</topic><topic>706/648/236</topic><topic>Agriculture</topic><topic>Animal Genetics and Genomics</topic><topic>Animals</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Cytology</topic><topic>Developmental genetics</topic><topic>DNA methylation</topic><topic>Enzymes</topic><topic>Epigenesis, Genetic - physiology</topic><topic>Evolution, Molecular</topic><topic>Gene expression</topic><topic>Gene Function</topic><topic>Genome, Human - physiology</topic><topic>Genomes</topic><topic>History</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Hypotheses</topic><topic>MicroRNAs</topic><topic>Molecular biology</topic><topic>Mutation</topic><topic>Physiological aspects</topic><topic>Polypeptides</topic><topic>Proteins</topic><topic>RNA</topic><topic>RNA, Untranslated - physiology</topic><topic>timeline</topic><topic>Transfer RNA</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morris, Kevin V.</creatorcontrib><creatorcontrib>Mattick, John S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nature reviews. Genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morris, Kevin V.</au><au>Mattick, John S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The rise of regulatory RNA</atitle><jtitle>Nature reviews. Genetics</jtitle><stitle>Nat Rev Genet</stitle><addtitle>Nat Rev Genet</addtitle><date>2014-06-01</date><risdate>2014</risdate><volume>15</volume><issue>6</issue><spage>423</spage><epage>437</epage><pages>423-437</pages><issn>1471-0056</issn><eissn>1471-0064</eissn><abstract>Discoveries over the past decade portend a paradigm shift in molecular biology; evidence suggests that RNA is not only functional as a messenger between DNA and protein but also involved in the regulation of genome organization and gene expression. This Timeline article surveys the emergence of the previously unsuspected world of regulatory RNA from a historical perspective.
Discoveries over the past decade portend a paradigm shift in molecular biology. Evidence suggests that RNA is not only functional as a messenger between DNA and protein but also involved in the regulation of genome organization and gene expression, which is increasingly elaborate in complex organisms. Regulatory RNA seems to operate at many levels; in particular, it plays an important part in the epigenetic processes that control differentiation and development. These discoveries suggest a central role for RNA in human evolution and ontogeny. Here, we review the emergence of the previously unsuspected world of regulatory RNA from a historical perspective.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>24776770</pmid><doi>10.1038/nrg3722</doi><tpages>15</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 631/337/384 631/337/384/2053 631/337/384/2568 706/648/236 Agriculture Animal Genetics and Genomics Animals Biomedicine Cancer Research Cytology Developmental genetics DNA methylation Enzymes Epigenesis, Genetic - physiology Evolution, Molecular Gene expression Gene Function Genome, Human - physiology Genomes History Human Genetics Humans Hypotheses MicroRNAs Molecular biology Mutation Physiological aspects Polypeptides Proteins RNA RNA, Untranslated - physiology timeline Transfer RNA |
| title | The rise of regulatory RNA |
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