Naphthoquinone Derivative PPE8 Induces Endoplasmic Reticulum Stress in p53 Null H1299 Cells

Endoplasmic reticulum (ER) plays a key role in synthesizing secretory proteins and sensing signal function in eukaryotic cells. Responding to calcium disturbance, oxidation state change, or pharmacological agents, ER transmembrane protein, inositol-regulating enzyme 1 (IRE1), senses the stress and t...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2015-01, Vol.2015 (2015), p.1-10
Hauptverfasser:	Lu, Te-Ling, Kuo, Yueh-Hsiung, Lee, Hong-Zin, Sung, Ping-Jyun, Tseng, Chih-Hsiang, Lu, Te-Jung, Huang, Chien-Chun, Lien, Jin-Cherng, Bao, Bo-Ying
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis B cells Biotechnology Cell cycle Cell growth Cell Line, Tumor Cell Survival - drug effects Cytotoxicity Endoplasmic reticulum Endoplasmic Reticulum Stress - drug effects Endoribonucleases - antagonists & inhibitors Endoribonucleases - genetics Endoribonucleases - metabolism Enzymes Ethylenediamines - chemical synthesis Ethylenediamines - chemistry Ethylenediamines - toxicity Heat-Shock Proteins - metabolism Humans Immunoglobulins Inositol JNK Mitogen-Activated Protein Kinases - metabolism Kinases Lung cancer Marine biology Naphthoquinones - chemical synthesis Naphthoquinones - chemistry Naphthoquinones - toxicity Phosphorylation Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism RNA Interference RNA, Small Interfering - metabolism Science Tumor proteins Tumor Suppressor Protein p53 - antagonists & inhibitors Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism
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