Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth

Tumour-associated macrophages (TAMs) are enriched in glioblastoma multiformes (GBMs) that contain glioma stem cells (GSCs) at the apex of their cellular hierarchy. The correlation between TAM density and glioma grade suggests a supportive role for TAMs in tumour progression. Here we interrogated the...

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Veröffentlicht in:	Nature cell biology 2015-02, Vol.17 (2), p.170-182
Hauptverfasser:	Zhou, Wenchao, Ke, Susan Q., Huang, Zhi, Flavahan, William, Fang, Xiaoguang, Paul, Jeremy, Wu, Ling, Sloan, Andrew E., McLendon, Roger E., Li, Xiaoxia, Rich, Jeremy N., Bao, Shideng
Format:	Artikel
Sprache:	eng
Schlagworte:	13/100 13/105 14/5 14/63 38/89 631/67 631/67/327 631/67/71 64/60 82/51 Animals Brain Neoplasms - blood Brain Neoplasms - metabolism Brain Neoplasms - pathology Cancer Research Cell Adhesion Molecules - metabolism Cell Biology Cell Count Cell Line, Tumor Cell Proliferation Cellular proteins Chemotactic Factors - metabolism Development and progression Developmental Biology Female Fluorescent Antibody Technique Gene Silencing Genetic aspects Glioblastoma - blood Glioblastoma - metabolism Glioblastoma - pathology Glioblastoma multiforme Humans Immune response Integrin alphaVbeta3 - metabolism Life Sciences Luminescent Measurements Macrophages - metabolism Mice, Inbred C57BL Monocytes - metabolism Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Properties RNA, Small Interfering - metabolism Signal Transduction Stem Cells Survival Analysis Tumors Xenograft Model Antitumor Assays
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