Aspergillus flavus endocarditis of the native mitral valve in a bone marrow transplant patient
Infective endocarditis due to Aspergillus species is an uncommon infection with a high mortality rate. It mostly occurs after the implantation of prosthetic heart valves. Parenteral nutrition, immunosuppression, broad-spectrum antibiotic regimens, and illegal intravenous drug use are the risk factor...
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| Veröffentlicht in: | The American journal of case reports 2015-01, Vol.16, p.25-30 |
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| container_title | The American journal of case reports |
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| creator | Demir, Tolga Ergenoglu, Mehmet Umit Ekinci, Abdurrahman Tanrikulu, Nursen Sahin, Mazlum Demirsoy, Ergun |
| description | Infective endocarditis due to Aspergillus species is an uncommon infection with a high mortality rate. It mostly occurs after the implantation of prosthetic heart valves. Parenteral nutrition, immunosuppression, broad-spectrum antibiotic regimens, and illegal intravenous drug use are the risk factors for developing infection.
We report a case of Aspergillus flavus native mitral valve endocarditis in a patient who had allogeneic stem cell transplantation in the past due to myelodysplastic syndrome.
Although it is rare and there is limited experience available with the diagnosis and treatment, early recognition and therapeutic intervention with systemic antifungal therapy and aggressive surgical intervention are critical to prevent further complications that may eventually lead to death. In addition, better novel diagnostic tools are needed to facilitate more accurate identification of patients with invasive Aspergillus and to permit earlier initiation of antifungal treatment. |
| doi_str_mv | 10.12659/AJCR.892428 |
| format | Article |
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We report a case of Aspergillus flavus native mitral valve endocarditis in a patient who had allogeneic stem cell transplantation in the past due to myelodysplastic syndrome.
Although it is rare and there is limited experience available with the diagnosis and treatment, early recognition and therapeutic intervention with systemic antifungal therapy and aggressive surgical intervention are critical to prevent further complications that may eventually lead to death. In addition, better novel diagnostic tools are needed to facilitate more accurate identification of patients with invasive Aspergillus and to permit earlier initiation of antifungal treatment.</description><identifier>ISSN: 1941-5923</identifier><identifier>EISSN: 1941-5923</identifier><identifier>DOI: 10.12659/AJCR.892428</identifier><identifier>PMID: 25603977</identifier><language>eng</language><publisher>United States: International Scientific Literature, Inc</publisher><subject>Adult ; Antifungal Agents - therapeutic use ; Aspergillus flavus - isolation & purification ; Bone Marrow Transplantation - adverse effects ; Endocarditis, Bacterial - diagnosis ; Endocarditis, Bacterial - drug therapy ; Endocarditis, Bacterial - etiology ; Heart Valve Prosthesis - adverse effects ; Heart Valve Prosthesis - microbiology ; Humans ; Male ; Mitral Valve - microbiology ; Mitral Valve - surgery ; Myelodysplastic Syndromes - surgery ; Tomography, X-Ray Computed</subject><ispartof>The American journal of case reports, 2015-01, Vol.16, p.25-30</ispartof><rights>Am J Case Rep, 2015 2015</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-ed910f3f1d8e6f4295d6eafce596c79d6ad2f5e05d22909cb24a86ae27db829b3</citedby><cites>FETCH-LOGICAL-c384t-ed910f3f1d8e6f4295d6eafce596c79d6ad2f5e05d22909cb24a86ae27db829b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311906/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311906/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25603977$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Demir, Tolga</creatorcontrib><creatorcontrib>Ergenoglu, Mehmet Umit</creatorcontrib><creatorcontrib>Ekinci, Abdurrahman</creatorcontrib><creatorcontrib>Tanrikulu, Nursen</creatorcontrib><creatorcontrib>Sahin, Mazlum</creatorcontrib><creatorcontrib>Demirsoy, Ergun</creatorcontrib><title>Aspergillus flavus endocarditis of the native mitral valve in a bone marrow transplant patient</title><title>The American journal of case reports</title><addtitle>Am J Case Rep</addtitle><description>Infective endocarditis due to Aspergillus species is an uncommon infection with a high mortality rate. It mostly occurs after the implantation of prosthetic heart valves. Parenteral nutrition, immunosuppression, broad-spectrum antibiotic regimens, and illegal intravenous drug use are the risk factors for developing infection.
We report a case of Aspergillus flavus native mitral valve endocarditis in a patient who had allogeneic stem cell transplantation in the past due to myelodysplastic syndrome.
Although it is rare and there is limited experience available with the diagnosis and treatment, early recognition and therapeutic intervention with systemic antifungal therapy and aggressive surgical intervention are critical to prevent further complications that may eventually lead to death. In addition, better novel diagnostic tools are needed to facilitate more accurate identification of patients with invasive Aspergillus and to permit earlier initiation of antifungal treatment.</description><subject>Adult</subject><subject>Antifungal Agents - therapeutic use</subject><subject>Aspergillus flavus - isolation & purification</subject><subject>Bone Marrow Transplantation - adverse effects</subject><subject>Endocarditis, Bacterial - diagnosis</subject><subject>Endocarditis, Bacterial - drug therapy</subject><subject>Endocarditis, Bacterial - etiology</subject><subject>Heart Valve Prosthesis - adverse effects</subject><subject>Heart Valve Prosthesis - microbiology</subject><subject>Humans</subject><subject>Male</subject><subject>Mitral Valve - microbiology</subject><subject>Mitral Valve - surgery</subject><subject>Myelodysplastic Syndromes - surgery</subject><subject>Tomography, X-Ray Computed</subject><issn>1941-5923</issn><issn>1941-5923</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkc9PwyAUx4nRuGXu5tlw9GBnoS0tF5Nl8WeWmBi9Smh5bJiuVOhq_O9lbi6TywPeJ9_3hS9C5ySeEMoyfj19mr1MCk5TWhyhIeEpiTJOk-OD_QCNvf-Iw2KU5TQ5RQOasTjheT5E71PfgluYul57rGvZhwKNspV0ynTGY6txtwTcyM70gFemc7LGvazDwTRY4tI24Vo6Z79w6DW-rWXT4Tbw0HRn6ETL2sN4V0fo7e72dfYQzZ_vH2fTeVQlRdpFoDiJdaKJKoDplPJMMZC6goyzKueKSUV1BnGmKOUxr0qayoJJoLkqC8rLZIRutrrtulyBqsLo4FO0zgRr38JKI_53GrMUC9uLNCGExywIXO4EnP1cg-_EyvgK6vAYsGsvCMs2f0zTDXq1RStnvXeg92NILH5TEZtUxDaVgF8cWtvDfxkkPws0irs</recordid><startdate>20150121</startdate><enddate>20150121</enddate><creator>Demir, Tolga</creator><creator>Ergenoglu, Mehmet Umit</creator><creator>Ekinci, Abdurrahman</creator><creator>Tanrikulu, Nursen</creator><creator>Sahin, Mazlum</creator><creator>Demirsoy, Ergun</creator><general>International Scientific Literature, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150121</creationdate><title>Aspergillus flavus endocarditis of the native mitral valve in a bone marrow transplant patient</title><author>Demir, Tolga ; Ergenoglu, Mehmet Umit ; Ekinci, Abdurrahman ; Tanrikulu, Nursen ; Sahin, Mazlum ; Demirsoy, Ergun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-ed910f3f1d8e6f4295d6eafce596c79d6ad2f5e05d22909cb24a86ae27db829b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Antifungal Agents - therapeutic use</topic><topic>Aspergillus flavus - isolation & purification</topic><topic>Bone Marrow Transplantation - adverse effects</topic><topic>Endocarditis, Bacterial - diagnosis</topic><topic>Endocarditis, Bacterial - drug therapy</topic><topic>Endocarditis, Bacterial - etiology</topic><topic>Heart Valve Prosthesis - adverse effects</topic><topic>Heart Valve Prosthesis - microbiology</topic><topic>Humans</topic><topic>Male</topic><topic>Mitral Valve - microbiology</topic><topic>Mitral Valve - surgery</topic><topic>Myelodysplastic Syndromes - surgery</topic><topic>Tomography, X-Ray Computed</topic><toplevel>online_resources</toplevel><creatorcontrib>Demir, Tolga</creatorcontrib><creatorcontrib>Ergenoglu, Mehmet Umit</creatorcontrib><creatorcontrib>Ekinci, Abdurrahman</creatorcontrib><creatorcontrib>Tanrikulu, Nursen</creatorcontrib><creatorcontrib>Sahin, Mazlum</creatorcontrib><creatorcontrib>Demirsoy, Ergun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The American journal of case reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Demir, Tolga</au><au>Ergenoglu, Mehmet Umit</au><au>Ekinci, Abdurrahman</au><au>Tanrikulu, Nursen</au><au>Sahin, Mazlum</au><au>Demirsoy, Ergun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aspergillus flavus endocarditis of the native mitral valve in a bone marrow transplant patient</atitle><jtitle>The American journal of case reports</jtitle><addtitle>Am J Case Rep</addtitle><date>2015-01-21</date><risdate>2015</risdate><volume>16</volume><spage>25</spage><epage>30</epage><pages>25-30</pages><issn>1941-5923</issn><eissn>1941-5923</eissn><abstract>Infective endocarditis due to Aspergillus species is an uncommon infection with a high mortality rate. It mostly occurs after the implantation of prosthetic heart valves. Parenteral nutrition, immunosuppression, broad-spectrum antibiotic regimens, and illegal intravenous drug use are the risk factors for developing infection.
We report a case of Aspergillus flavus native mitral valve endocarditis in a patient who had allogeneic stem cell transplantation in the past due to myelodysplastic syndrome.
Although it is rare and there is limited experience available with the diagnosis and treatment, early recognition and therapeutic intervention with systemic antifungal therapy and aggressive surgical intervention are critical to prevent further complications that may eventually lead to death. In addition, better novel diagnostic tools are needed to facilitate more accurate identification of patients with invasive Aspergillus and to permit earlier initiation of antifungal treatment.</abstract><cop>United States</cop><pub>International Scientific Literature, Inc</pub><pmid>25603977</pmid><doi>10.12659/AJCR.892428</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The American journal of case reports, 2015-01, Vol.16, p.25-30 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adult Antifungal Agents - therapeutic use Aspergillus flavus - isolation & purification Bone Marrow Transplantation - adverse effects Endocarditis, Bacterial - diagnosis Endocarditis, Bacterial - drug therapy Endocarditis, Bacterial - etiology Heart Valve Prosthesis - adverse effects Heart Valve Prosthesis - microbiology Humans Male Mitral Valve - microbiology Mitral Valve - surgery Myelodysplastic Syndromes - surgery Tomography, X-Ray Computed |
| title | Aspergillus flavus endocarditis of the native mitral valve in a bone marrow transplant patient |
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