Aging and DNA methylation
In this Opinion article, we summarize how changes in DNA methylation occur during aging in mammals and discuss examples of how such events may contribute to the aging process. We explore mechanisms that could facilitate DNA methylation changes in a site-specific manner and highlight a model in which...
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| Veröffentlicht in: | BMC biology 2015-01, Vol.13 (1), p.7-7, Article 7 |
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| container_title | BMC biology |
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| creator | Jung, Marc Pfeifer, Gerd P |
| description | In this Opinion article, we summarize how changes in DNA methylation occur during aging in mammals and discuss examples of how such events may contribute to the aging process. We explore mechanisms that could facilitate DNA methylation changes in a site-specific manner and highlight a model in which region-specific DNA hypermethylation during aging is facilitated in a competitive manner by destabilization of the Polycomb repressive complex. |
| doi_str_mv | 10.1186/s12915-015-0118-4 |
| format | Article |
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| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; SpringerLink Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access; Springer Nature OA Free Journals |
| subjects | Aging - genetics Animals Cellular Senescence Disease - genetics DNA Methylation - genetics Genetic aspects Humans Opinion Organ Specificity - genetics Physiological aspects Stem Cells - metabolism Type 2 diabetes |
| title | Aging and DNA methylation |
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