Effects of the novel, selective and low-efficacy mu opioid receptor ligand NAQ on intracranial self-stimulation in rats

Rationale Low-efficacy mu opioid receptor agonists may be useful for some clinical indications, but clinically available low-efficacy mu agonists also have low selectivity for mu vs. kappa opioid receptors. NAQ (17-cyclopropylmethyl-3,14ß-dihydroxy-4,5α-epoxy-6α-[(3′-isoquinolyl)acetamido]morphinan)...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Psychopharmacology 2015-02, Vol.232 (4), p.815-824
Hauptverfasser:	Altarifi, Ahmad A., Yuan, Yunyun, Zhang, Yan, Selley, Dana E., Negus, S. Stevens
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal behavior Animals Biomedical and Life Sciences Biomedicine Brain - drug effects Brain - metabolism Brain - physiology Complications and side effects Dosage and administration Electrodes, Implanted Genetic aspects Ligands Male Medial Forebrain Bundle - drug effects Morphinans - pharmacology Morphine Narcotics Neurosciences Opioid receptors Original Investigation Pharmacology/Toxicology Physiological aspects Psychiatry Psychopharmacology Rats Rats, Sprague-Dawley Receptors, Opioid, kappa - agonists Receptors, Opioid, kappa - metabolism Receptors, Opioid, mu - agonists Receptors, Opioid, mu - metabolism Rodents Self Stimulation - drug effects Substrate Specificity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!