28S rRNA is inducibly pseudouridylated by the mTOR pathway translational control in CHO cell cultures

•We first identified and sequenced snoRNA U19 in CHO cells.•snoRNA U19 is a down-stream effector of the mTOR pathway in CHO cells.•snoRNAs can be considered as potential cell engineering targets to enhance the cellular growth in CHO cell cultures. The mTOR pathway is a conserved master regulator of...

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Veröffentlicht in:	Journal of biotechnology 2014-03, Vol.174, p.16-21
Hauptverfasser:	Courtes, Franck C., Gu, Chen, Wong, Niki S.C., Dedon, Peter C., Yap, Miranda G.S., Lee, Dong-Yup
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence CHO Cells CHO cells culture Cricetulus Gene Expression Regulation - drug effects Humans Inducible pseudouridylation Molecular Sequence Data mTOR pathway Pseudouridine - metabolism Ribosomes - drug effects Ribosomes - physiology RNA, Ribosomal, 28S - metabolism RNA, Small Nucleolar - genetics Sequence Alignment Signal Transduction - drug effects Sirolimus - pharmacology snoRNA U19 TOR Serine-Threonine Kinases - metabolism Translatome
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