Renal F4/80+ CD11c+ mononuclear phagocytes display phenotypic and functional characteristics of macrophages in health and in adriamycin nephropathy

Conventional markers of macrophages (Mфs) and dendritic cells (DCs) lack specificity and often overlap, leading to confusion and controversy regarding the precise function of these cells in kidney and other diseases. This study aimed to identify the phenotype and function of renal mononuclear phagoc...

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Veröffentlicht in:	Journal of the American Society of Nephrology 2015-02, Vol.26 (2), p.349-363
Hauptverfasser:	Cao, Qi, Wang, Yiping, Wang, Xin Maggie, Lu, Junyu, Lee, Vincent W S, Ye, Qianling, Nguyen, Hanh, Zheng, Guoping, Zhao, Ye, Alexander, Stephen I, Harris, David C H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Animals Antigens, CD - metabolism Antigens, Differentiation - metabolism Antigens, Differentiation, Myelomonocytic - metabolism Basic Research Biomarkers - metabolism CD11 Antigens - metabolism Disease Models, Animal Doxorubicin - adverse effects In Vitro Techniques Kidney - pathology Kidney - physiology Kidney Diseases - chemically induced Kidney Diseases - pathology Kidney Diseases - physiopathology Lectins, C-Type - metabolism Macrophages - immunology Macrophages - pathology Macrophages - physiology Mannose-Binding Lectins - metabolism Mice Mice, Inbred BALB C Mice, Inbred C57BL Phagocytes - immunology Phagocytes - pathology Phagocytes - physiology Phenotype Receptors, Cell Surface - metabolism Scavenger Receptors, Class A - metabolism
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