Antifailure Therapy Including Spironolactone Improves Left Ventricular Energy Supply‐Demand Relations in Nonischemic Dilated Cardiomyopathy

Background Left ventricular (LV) energy supply‐demand imbalance is postulated to cause “energy starvation” and contribute to heart failure (HF) in nonischemic dilated cardiomyopathy (NIDCM). Using cardiac magnetic resonance (CMR) and [11C] acetate positron emission tomography (PET), we evaluated LV...

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Veröffentlicht in:	Journal of the American Heart Association 2014-08, Vol.3 (4), p.n/a
Hauptverfasser:	Bell, Susan P., Adkisson, Douglas W., Lawson, Mark A., Wang, Li, Ooi, Henry, Sawyer, Douglas B., Kronenberg, Marvin W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cardiomyopathy, Dilated - complications Cardiomyopathy, Dilated - diagnostic imaging Cardiomyopathy, Dilated - drug therapy Energy Metabolism Female heart failure Heart Failure - diagnostic imaging Heart Failure - drug therapy Heart Failure - etiology Heart Ventricles - diagnostic imaging Heart Ventricles - metabolism Humans Magnetic Resonance Imaging Magnetic Resonance Imaging, Cine Male Middle Aged Mineralocorticoid Receptor Antagonists - therapeutic use Myocardial Perfusion Imaging Myocardium - metabolism Original Research Positron-Emission Tomography Spironolactone - therapeutic use Ventricular Function, Left
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