Development and Evaluation of Avanafil Self-nanoemulsifying Drug Delivery System with Rapid Onset of Action and Enhanced Bioavailability

Utilization of lipid-based drug delivery systems has recently gained focus for drugs characterized by poor aqueous solubility. The improved aqueous solubility overcomes one of the main barriers that limit their bioavailability. The objective of this work was to improve the solubility and oral bioava...

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Veröffentlicht in:	AAPS PharmSciTech 2015-02, Vol.16 (1), p.53-58
Hauptverfasser:	Fahmy, Usama A., Ahmed, Osama A. A., Hosny, Khaled M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Biochemistry Biological Availability Biomedical and Life Sciences Biomedicine Biotechnology Diffusion Drug Compounding - methods Drug Stability Emulsifying Agents - chemistry Emulsions Male Metabolic Clearance Rate Nanocapsules - administration & dosage Nanocapsules - chemistry Nanocapsules - ultrastructure Particle Size Pharmacology/Toxicology Pharmacy Phase Transition Pyrimidines - administration & dosage Pyrimidines - blood Pyrimidines - chemistry Pyrimidines - pharmacokinetics Rats Rats, Wistar Research Article
Online-Zugang:	Volltext
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