Alginate-peptide amphiphile core-shell microparticles as a targeted drug delivery system

We describe in this work the synthesis of microparticles with a doxorubicin drug conjugated alginate core and a shell of peptide amphiphile nanofibres functionalized for targeting the folate receptor. The spherical geometry of the particle core allows high drug loading per surface area, whereas the...

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Veröffentlicht in:	RSC advances 2015-01, Vol.5 (12), p.8753-8756
Hauptverfasser:	Boekhoven, Job, Zha, R Helen, Tantakitti, Faifan, Zhuang, Ellen, Zandi, Roya, Newcomb, Christina J, Stupp, Samuel I
Format:	Artikel
Sprache:	eng
Schlagworte:	alginates breast neoplasms catalysis (homogeneous), solar (photovoltaic), bio-inspired, charge transport, mesostructured materials, materials and chemistry by design, synthesis (novel materials), synthesis (self-assembly) cytotoxicity doxorubicin drug delivery systems Drugs folate receptors geometry Microparticles nanofibers Nanostructure neoplasm cells Peptides Receptors Self assembly Shells Surface area surfactants Synthesis
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