Biosynthesis of Versipelostatin: Identification of an Enzyme-Catalyzed [4+2]-Cycloaddition Required for Macrocyclization of Spirotetronate-Containing Polyketides

Versipelostatin (VST) is an unusual 17-membered macrocyclic polyketide product that contains a spirotetronate skeleton. In this study, the entire VST biosynthetic gene cluster (vst) spanning 108 kb from Streptomyces versipellis 4083-SVS6 was identified by heterologous expression using a bacterial ar...

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Veröffentlicht in:	Journal of the American Chemical Society 2015-01, Vol.137 (2), p.572-575
Hauptverfasser:	Hashimoto, Takuya, Hashimoto, Junko, Teruya, Kuniko, Hirano, Takashi, Shin-ya, Kazuo, Ikeda, Haruo, Liu, Hung-wen, Nishiyama, Makoto, Kuzuyama, Tomohisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteria Biocatalysis Biosynthesis Clusters Communication Cycloaddition Reaction Gene expression Genes Macrocyclic compounds Macrolides Mathematical analysis Multigene Family Olefins Oligosaccharides - biosynthesis Polyketides - chemistry Polyketides - metabolism Spiro Compounds - chemistry Stereoisomerism Streptomyces - enzymology Streptomyces - genetics Streptomyces - metabolism Substrate Specificity Vectors (mathematics)
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