Central Adiposity Is Negatively Associated with Hippocampal-Dependent Relational Memory among Overweight and Obese Children
Objective To assess associations between adiposity and hippocampal-dependent and hippocampal-independent memory forms among prepubertal children. Study design Prepubertal children (age 7-9 years; n = 126), classified as non-overweight (
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| Veröffentlicht in: | The Journal of pediatrics 2015-02, Vol.166 (2), p.302-308.e1 |
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| container_title | The Journal of pediatrics |
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| creator | Khan, Naiman A., PhD, RD Baym, Carol L., PhD Monti, Jim M., PhD Raine, Lauren B., BS Drollette, Eric S., BS Scudder, Mark R., BS Moore, R. Davis, PhD Kramer, Arthur F., PhD Hillman, Charles H., PhD Cohen, Neal J., PhD |
| description | Objective To assess associations between adiposity and hippocampal-dependent and hippocampal-independent memory forms among prepubertal children. Study design Prepubertal children (age 7-9 years; n = 126), classified as non-overweight ( |
| doi_str_mv | 10.1016/j.jpeds.2014.10.008 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4308543</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0022347614009536</els_id><sourcerecordid>1652425940</sourcerecordid><originalsourceid>FETCH-LOGICAL-c514t-6f5ac80ea1cdb10df7da61a6742720ea1c60120d7f5ec10346f95981308044d03</originalsourceid><addsrcrecordid>eNqFUsuO0zAUjRCIKQNfgIS8ZJNyHTuvBSNV5TEjDVTisbZc-6Z1cOKMnXYU8fM402EEbFhZOj7n3Me5SfKSwpICLd60y3ZAHZYZUB6RJUD1KFlQqMu0qBh7nCwAsixlvCzOkmchtABQc4CnyVmW85zXrF4kP9fYj15astJmcMGME7kK5DPu5GiOaCeyCsEpI0fU5NaMe3JphsEp2Q3Spu9wwF5HA_IFbRS4Php9ws75icjO9TuyOaK_RbPbj0T2mmy2GJCs98Zqj_3z5EkjbcAX9-958v3D-2_ry_R68_FqvbpOVU75mBZNLlUFKKnSWwq6KbUsqCxKnpXZHVwAzUCXTY6KAuNFU-d1RRlUwLkGdp5cnHyHw7ZDrU4Ti8GbTvpJOGnE3z-92YudOwoeLXLOosHrewPvbg4YRtGZoNBa2aM7BEGLPONZHpcbqexEVd6F4LF5KENBzLGJVtzFJubYZjDGFlWv_uzwQfM7p0h4eyJg3NPRoBdBGewVauNRjUI7858CF__olTW9UdL-wAlD6w4-ZhcnESETIL7OlzMfDo33UuesYL8AjfXBcw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1652425940</pqid></control><display><type>article</type><title>Central Adiposity Is Negatively Associated with Hippocampal-Dependent Relational Memory among Overweight and Obese Children</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Khan, Naiman A., PhD, RD ; Baym, Carol L., PhD ; Monti, Jim M., PhD ; Raine, Lauren B., BS ; Drollette, Eric S., BS ; Scudder, Mark R., BS ; Moore, R. Davis, PhD ; Kramer, Arthur F., PhD ; Hillman, Charles H., PhD ; Cohen, Neal J., PhD</creator><creatorcontrib>Khan, Naiman A., PhD, RD ; Baym, Carol L., PhD ; Monti, Jim M., PhD ; Raine, Lauren B., BS ; Drollette, Eric S., BS ; Scudder, Mark R., BS ; Moore, R. Davis, PhD ; Kramer, Arthur F., PhD ; Hillman, Charles H., PhD ; Cohen, Neal J., PhD</creatorcontrib><description>Objective To assess associations between adiposity and hippocampal-dependent and hippocampal-independent memory forms among prepubertal children. Study design Prepubertal children (age 7-9 years; n = 126), classified as non-overweight (<85th percentile body mass index [BMI]-for-age [n = 73]) or overweight/obese (≥85th percentile BMI-for-age [n = 53]), completed relational (hippocampal-dependent) and item (hippocampal-independent) memory tasks. Performance was assessed with both direct (behavioral accuracy) and indirect (preferential disproportionate viewing [PDV]) measures. Adiposity (ie, percent whole-body fat mass, subcutaneous abdominal adipose tissue, visceral adipose tissue, and total abdominal adipose tissue) was assessed by dual-energy X-ray absorptiometry. Backward regression identified significant ( P < .05) predictive models of memory performance. Covariates included age, sex, pubertal timing, socioeconomic status (SES), IQ, oxygen consumption, and BMI z -score. Results Among overweight/obese children, total abdominal adipose tissue was a significant negative predictor of relational memory behavioral accuracy, and pubertal timing together with SES jointly predicted the PDV measure of relational memory. In contrast, among non-overweight children, male sex predicted item memory behavioral accuracy, and a model consisting of SES and BMI z -score jointly predicted the PDV measure of relational memory. Conclusion Regional, but not whole-body, fat deposition was selectively and negatively associated with hippocampal-dependent relational memory among overweight/obese prepubertal children.</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/j.jpeds.2014.10.008</identifier><identifier>PMID: 25454939</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adiposity ; Body Mass Index ; Child ; Female ; Hippocampus - physiology ; Humans ; Male ; Memory - physiology ; Overweight - physiopathology ; Overweight - psychology ; Pediatric Obesity - physiopathology ; Pediatric Obesity - psychology ; Pediatrics</subject><ispartof>The Journal of pediatrics, 2015-02, Vol.166 (2), p.302-308.e1</ispartof><rights>Elsevier Inc.</rights><rights>2015 Elsevier Inc.</rights><rights>Copyright © 2015 Elsevier Inc. All rights reserved.</rights><rights>2014 Elsevier Inc. All rights reserved. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c514t-6f5ac80ea1cdb10df7da61a6742720ea1c60120d7f5ec10346f95981308044d03</citedby><cites>FETCH-LOGICAL-c514t-6f5ac80ea1cdb10df7da61a6742720ea1c60120d7f5ec10346f95981308044d03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0022347614009536$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25454939$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khan, Naiman A., PhD, RD</creatorcontrib><creatorcontrib>Baym, Carol L., PhD</creatorcontrib><creatorcontrib>Monti, Jim M., PhD</creatorcontrib><creatorcontrib>Raine, Lauren B., BS</creatorcontrib><creatorcontrib>Drollette, Eric S., BS</creatorcontrib><creatorcontrib>Scudder, Mark R., BS</creatorcontrib><creatorcontrib>Moore, R. Davis, PhD</creatorcontrib><creatorcontrib>Kramer, Arthur F., PhD</creatorcontrib><creatorcontrib>Hillman, Charles H., PhD</creatorcontrib><creatorcontrib>Cohen, Neal J., PhD</creatorcontrib><title>Central Adiposity Is Negatively Associated with Hippocampal-Dependent Relational Memory among Overweight and Obese Children</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>Objective To assess associations between adiposity and hippocampal-dependent and hippocampal-independent memory forms among prepubertal children. Study design Prepubertal children (age 7-9 years; n = 126), classified as non-overweight (<85th percentile body mass index [BMI]-for-age [n = 73]) or overweight/obese (≥85th percentile BMI-for-age [n = 53]), completed relational (hippocampal-dependent) and item (hippocampal-independent) memory tasks. Performance was assessed with both direct (behavioral accuracy) and indirect (preferential disproportionate viewing [PDV]) measures. Adiposity (ie, percent whole-body fat mass, subcutaneous abdominal adipose tissue, visceral adipose tissue, and total abdominal adipose tissue) was assessed by dual-energy X-ray absorptiometry. Backward regression identified significant ( P < .05) predictive models of memory performance. Covariates included age, sex, pubertal timing, socioeconomic status (SES), IQ, oxygen consumption, and BMI z -score. Results Among overweight/obese children, total abdominal adipose tissue was a significant negative predictor of relational memory behavioral accuracy, and pubertal timing together with SES jointly predicted the PDV measure of relational memory. In contrast, among non-overweight children, male sex predicted item memory behavioral accuracy, and a model consisting of SES and BMI z -score jointly predicted the PDV measure of relational memory. Conclusion Regional, but not whole-body, fat deposition was selectively and negatively associated with hippocampal-dependent relational memory among overweight/obese prepubertal children.</description><subject>Adiposity</subject><subject>Body Mass Index</subject><subject>Child</subject><subject>Female</subject><subject>Hippocampus - physiology</subject><subject>Humans</subject><subject>Male</subject><subject>Memory - physiology</subject><subject>Overweight - physiopathology</subject><subject>Overweight - psychology</subject><subject>Pediatric Obesity - physiopathology</subject><subject>Pediatric Obesity - psychology</subject><subject>Pediatrics</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUsuO0zAUjRCIKQNfgIS8ZJNyHTuvBSNV5TEjDVTisbZc-6Z1cOKMnXYU8fM402EEbFhZOj7n3Me5SfKSwpICLd60y3ZAHZYZUB6RJUD1KFlQqMu0qBh7nCwAsixlvCzOkmchtABQc4CnyVmW85zXrF4kP9fYj15astJmcMGME7kK5DPu5GiOaCeyCsEpI0fU5NaMe3JphsEp2Q3Spu9wwF5HA_IFbRS4Php9ws75icjO9TuyOaK_RbPbj0T2mmy2GJCs98Zqj_3z5EkjbcAX9-958v3D-2_ry_R68_FqvbpOVU75mBZNLlUFKKnSWwq6KbUsqCxKnpXZHVwAzUCXTY6KAuNFU-d1RRlUwLkGdp5cnHyHw7ZDrU4Ti8GbTvpJOGnE3z-92YudOwoeLXLOosHrewPvbg4YRtGZoNBa2aM7BEGLPONZHpcbqexEVd6F4LF5KENBzLGJVtzFJubYZjDGFlWv_uzwQfM7p0h4eyJg3NPRoBdBGewVauNRjUI7858CF__olTW9UdL-wAlD6w4-ZhcnESETIL7OlzMfDo33UuesYL8AjfXBcw</recordid><startdate>20150201</startdate><enddate>20150201</enddate><creator>Khan, Naiman A., PhD, RD</creator><creator>Baym, Carol L., PhD</creator><creator>Monti, Jim M., PhD</creator><creator>Raine, Lauren B., BS</creator><creator>Drollette, Eric S., BS</creator><creator>Scudder, Mark R., BS</creator><creator>Moore, R. Davis, PhD</creator><creator>Kramer, Arthur F., PhD</creator><creator>Hillman, Charles H., PhD</creator><creator>Cohen, Neal J., PhD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150201</creationdate><title>Central Adiposity Is Negatively Associated with Hippocampal-Dependent Relational Memory among Overweight and Obese Children</title><author>Khan, Naiman A., PhD, RD ; Baym, Carol L., PhD ; Monti, Jim M., PhD ; Raine, Lauren B., BS ; Drollette, Eric S., BS ; Scudder, Mark R., BS ; Moore, R. Davis, PhD ; Kramer, Arthur F., PhD ; Hillman, Charles H., PhD ; Cohen, Neal J., PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c514t-6f5ac80ea1cdb10df7da61a6742720ea1c60120d7f5ec10346f95981308044d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adiposity</topic><topic>Body Mass Index</topic><topic>Child</topic><topic>Female</topic><topic>Hippocampus - physiology</topic><topic>Humans</topic><topic>Male</topic><topic>Memory - physiology</topic><topic>Overweight - physiopathology</topic><topic>Overweight - psychology</topic><topic>Pediatric Obesity - physiopathology</topic><topic>Pediatric Obesity - psychology</topic><topic>Pediatrics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khan, Naiman A., PhD, RD</creatorcontrib><creatorcontrib>Baym, Carol L., PhD</creatorcontrib><creatorcontrib>Monti, Jim M., PhD</creatorcontrib><creatorcontrib>Raine, Lauren B., BS</creatorcontrib><creatorcontrib>Drollette, Eric S., BS</creatorcontrib><creatorcontrib>Scudder, Mark R., BS</creatorcontrib><creatorcontrib>Moore, R. Davis, PhD</creatorcontrib><creatorcontrib>Kramer, Arthur F., PhD</creatorcontrib><creatorcontrib>Hillman, Charles H., PhD</creatorcontrib><creatorcontrib>Cohen, Neal J., PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khan, Naiman A., PhD, RD</au><au>Baym, Carol L., PhD</au><au>Monti, Jim M., PhD</au><au>Raine, Lauren B., BS</au><au>Drollette, Eric S., BS</au><au>Scudder, Mark R., BS</au><au>Moore, R. Davis, PhD</au><au>Kramer, Arthur F., PhD</au><au>Hillman, Charles H., PhD</au><au>Cohen, Neal J., PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Central Adiposity Is Negatively Associated with Hippocampal-Dependent Relational Memory among Overweight and Obese Children</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>2015-02-01</date><risdate>2015</risdate><volume>166</volume><issue>2</issue><spage>302</spage><epage>308.e1</epage><pages>302-308.e1</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><abstract>Objective To assess associations between adiposity and hippocampal-dependent and hippocampal-independent memory forms among prepubertal children. Study design Prepubertal children (age 7-9 years; n = 126), classified as non-overweight (<85th percentile body mass index [BMI]-for-age [n = 73]) or overweight/obese (≥85th percentile BMI-for-age [n = 53]), completed relational (hippocampal-dependent) and item (hippocampal-independent) memory tasks. Performance was assessed with both direct (behavioral accuracy) and indirect (preferential disproportionate viewing [PDV]) measures. Adiposity (ie, percent whole-body fat mass, subcutaneous abdominal adipose tissue, visceral adipose tissue, and total abdominal adipose tissue) was assessed by dual-energy X-ray absorptiometry. Backward regression identified significant ( P < .05) predictive models of memory performance. Covariates included age, sex, pubertal timing, socioeconomic status (SES), IQ, oxygen consumption, and BMI z -score. Results Among overweight/obese children, total abdominal adipose tissue was a significant negative predictor of relational memory behavioral accuracy, and pubertal timing together with SES jointly predicted the PDV measure of relational memory. In contrast, among non-overweight children, male sex predicted item memory behavioral accuracy, and a model consisting of SES and BMI z -score jointly predicted the PDV measure of relational memory. Conclusion Regional, but not whole-body, fat deposition was selectively and negatively associated with hippocampal-dependent relational memory among overweight/obese prepubertal children.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>25454939</pmid><doi>10.1016/j.jpeds.2014.10.008</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adiposity Body Mass Index Child Female Hippocampus - physiology Humans Male Memory - physiology Overweight - physiopathology Overweight - psychology Pediatric Obesity - physiopathology Pediatric Obesity - psychology Pediatrics |
| title | Central Adiposity Is Negatively Associated with Hippocampal-Dependent Relational Memory among Overweight and Obese Children |
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