Cyclooxygenase-2 and Cancer Treatment: Understanding the Risk Should Be Worth the Reward

Targeting the prostaglandin (PG) pathway is potentially a critical intervention for the prevention and treatment of cancer. Central to PG biosynthesis are two isoforms of cyclooxygenase (COX 1 and 2), which produce prostaglandin H(2) (PGH(2)) from plasma membrane stores of fatty acids. COX-1 is cons...

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Veröffentlicht in:	Clinical cancer research 2010-03, Vol.16 (5), p.1384-1390
Hauptverfasser:	MENTER, David G, SCHILSKY, Richard L, DUBOIS, Raymond N
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antineoplastic Agents - pharmacology Biological and medical sciences Cyclooxygenase 2 - genetics Cyclooxygenase 2 - metabolism Humans Medical sciences Neoplasms - drug therapy Neoplasms - enzymology Pharmacology. Drug treatments Prostaglandins - metabolism Risk Signal Transduction - physiology
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