Hydrostatic pressure influences HIF-2 alpha expression in chondrocytes

Hypoxia-inducible factor (HIF)-2α is considered to play a major role in the progression of osteoarthritis. Recently, it was reported that pressure amplitude influences HIF-2α expression in murine endothelial cells. We examined whether hydrostatic pressure is involved in expression of HIF-2α in artic...

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Veröffentlicht in:	International journal of molecular sciences 2015-01, Vol.16 (1), p.1043-1050
Hauptverfasser:	Inoue, Hiroaki, Arai, Yuji, Kishida, Tsunao, Terauchi, Ryu, Honjo, Kuniaki, Nakagawa, Shuji, Tsuchida, Shinji, Matsuki, Tomohiro, Ueshima, Keiichirou, Fujiwara, Hiroyoshi, Mazda, Osam, Kubo, Toshikazu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arthritis Basic Helix-Loop-Helix Transcription Factors - metabolism Cartilage Cells, Cultured Chondrocytes - cytology Chondrocytes - drug effects Chondrocytes - metabolism Fluid dynamics Gene expression Gene Expression Regulation - drug effects HSP70 Heat-Shock Proteins - metabolism Hydrostatic Pressure Hypoxia Inflammatory diseases Interleukin-1beta - pharmacology Male Matrix Metalloproteinase 13 - metabolism Matrix Metalloproteinase 3 - metabolism NF-kappa B - metabolism Rabbits Vascular Endothelial Growth Factor A - metabolism
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