Bacillus subtilis as heterologous host for the secretory production of the non-ribosomal cyclodepsipeptide enniatin

The heterologous expression of genes or gene clusters in microbial hosts, followed by metabolic engineering of biosynthetic pathways, is key to access industrially and pharmaceutically relevant compounds in an economically affordable and sustainable manner. Therefore, platforms need to be developed,...

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Veröffentlicht in:	Applied microbiology and biotechnology 2015-01, Vol.99 (2), p.681-691
Hauptverfasser:	Zobel, Sophia, Kumpfmüller, Jana, Süssmuth, Roderich D, Schweder, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Bacillus subtilis Bacillus subtilis - genetics Bacillus subtilis - metabolism Bioactive compounds bioactive properties biochemical pathways Biomedical and Life Sciences bioprocess engineering Biosynthesis Biotechnological Products and Process Engineering Biotechnology Cloning Cloning, Molecular Culture Media Depsipeptides - biosynthesis E coli Enzymes Fungi Gene expression Genetic aspects genetic background Genetic engineering Gram-positive bacteria Health aspects hosts Identification and classification Industrial Microbiology Life Sciences ligases metabolic engineering Metabolic Engineering - methods Metabolism Metabolites Microbial Genetics and Genomics Microbiology multigene family Observations Peptide Synthases - genetics Peptide Synthases - metabolism Peptides Plasmids Plasmids - genetics Promoter Regions, Genetic Secondary metabolites Streptococcus infections
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