Pharmacokinetics of Rac inhibitor EHop-016 in mice by ultra-performance liquid chromatography tandem mass spectrometry

•A rapid and sensitive method was validated for detection of EHop-016 in mouse plasma by UPLC/MS/MS.•EHop-016 pharmacokinetics in mice was quantified using a dosing scheme of 10, 20, and 40mg/kg BW.•EHop-016 is bioavailable after intraperitoneal and oral administration. The Rho GTPase Rac is an impo...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2015-02, Vol.981-982, p.19-26
Hauptverfasser:	Humphries-Bickley, Tessa, Castillo-Pichardo, Linette, Corujo-Carro, Francheska, Duconge, Jorge, Hernandez-O’Farrill, Eliud, Vlaar, Cornelis, Rodriguez-Orengo, Jose F., Cubano, Luis, Dharmawardhane, Suranganie
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bioavailability body weight breast neoplasms Cancer Carbazoles - blood Carbazoles - chemistry Carbazoles - pharmacokinetics cell movement Chromatography, High Pressure Liquid - methods Dosing EHop-016 Electric potential electrospray ionization mass spectrometry Female guanosinetriphosphatase half life Inhibitors Linear Models Mass spectrometry metastasis Methyl alcohol Mice Mice, Nude neoplasm cells Pharmacokinetics Pyrimidines - blood Pyrimidines - chemistry Pyrimidines - pharmacokinetics Rac rac GTP-Binding Proteins - antagonists & inhibitors Reproducibility of Results Sensitivity and Specificity tandem mass spectrometry Tandem Mass Spectrometry - methods therapeutics ultra-performance liquid chromatography UPLC/MS/MS Voltage
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