Expression of β-catenin in hepatocellular carcinoma
AIM: The β-catenin has been recognized as a critical member of the Wnt signaling pathway and plays an important role in the generation/differentiation of many tissues. Inappropriate activation of this pathway has been implicated in carcinogenesis. The mechanism underlying the development as well as...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2005-04, Vol.11 (16), p.2398-2401 |
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| container_title | World journal of gastroenterology : WJG |
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| creator | Tien, Liem Thanh Ito, Masahiro Nakao, Mikiko Niino, Daisuke Serik, Meirmanov Nakashima, Masahiro Wen, Chun-Yang Yatsuhashi, Hiroshi Ishibashi, Hiromi |
| description | AIM: The β-catenin has been recognized as a critical member of the Wnt signaling pathway and plays an important role in the generation/differentiation of many tissues. Inappropriate activation of this pathway has been implicated in carcinogenesis. The mechanism underlying the development as well as its prognosis of hepatocellular carcinoma (HCC) has remained unclear. The purpose of this study is to analyze the expression of β-catenin in HCC in relation to histological grades and viral hepatitis backgrounds. METHODS: Thirty-two sections were selected at random from autopsy and surgical cases of HCC. Immuohistologically, the location and positivity of β-catenin expression in HCC was examined. RESULTS: Normal hepatocytes did not express β-catenin. In 78% of HCC β-catenin was expressed at the membrane of the cells, with or without cytoplasmic and/or nuclear expression. The tumor cells with well- and moderately-differentiated grades expressed frequently at the membrane and cytoplasm compared with poorly-differentiated type. Nuclear expression of β-catenin was prone to occur in the tumor cells of poorly-differentiated grade. There were 15% of hepatitis C virus (HCV) backgrounds with nuclear expression. In contrast, there was 38% with nuclear expression in hepatitis B virus (HBV) backgrounds. In nonBnonC hepatitis, no case expressed nuclear β-catenin. CONCLUSION: The β-catenin expression in HCC cells was heterogenous among types of hepatitis viral infection. Wnt signaling pathway might be deeply involved in less-differentiated HCC and HBV background. |
| doi_str_mv | 10.3748/wjg.v11.i16.2398 |
| format | Article |
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Inappropriate activation of this pathway has been implicated in carcinogenesis. The mechanism underlying the development as well as its prognosis of hepatocellular carcinoma (HCC) has remained unclear. The purpose of this study is to analyze the expression of β-catenin in HCC in relation to histological grades and viral hepatitis backgrounds. METHODS: Thirty-two sections were selected at random from autopsy and surgical cases of HCC. Immuohistologically, the location and positivity of β-catenin expression in HCC was examined. RESULTS: Normal hepatocytes did not express β-catenin. In 78% of HCC β-catenin was expressed at the membrane of the cells, with or without cytoplasmic and/or nuclear expression. The tumor cells with well- and moderately-differentiated grades expressed frequently at the membrane and cytoplasm compared with poorly-differentiated type. Nuclear expression of β-catenin was prone to occur in the tumor cells of poorly-differentiated grade. There were 15% of hepatitis C virus (HCV) backgrounds with nuclear expression. In contrast, there was 38% with nuclear expression in hepatitis B virus (HBV) backgrounds. In nonBnonC hepatitis, no case expressed nuclear β-catenin. CONCLUSION: The β-catenin expression in HCC cells was heterogenous among types of hepatitis viral infection. Wnt signaling pathway might be deeply involved in less-differentiated HCC and HBV background.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v11.i16.2398</identifier><identifier>PMID: 15832407</identifier><language>eng</language><publisher>United States: Department of Pathology, National Nagasaki Medical Center, 2-1001-1 Kubara,Omura, Nagasaki 856-8562, Japan%Department of Molecular Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Science, 1-12-4 Sakamoto,Nagasaki 852-8523, Japan%Tissue and Histopathology Section Division of Scientific Data Registry, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Science, 1-12-4 Sakamoto,Nagasaki 852-8523, Japan%Department of Molecular Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Science, 1-12-4 Sakamoto,Nagasaki 852-8523, Japan</publisher><subject>Adult ; Aged ; Aged, 80 and over ; beta Catenin ; Carcinoma, Hepatocellular - metabolism ; Carcinoma, Hepatocellular - pathology ; Cytoskeletal Proteins - metabolism ; Female ; Hepatitis, Viral, Human - metabolism ; Hepatitis, Viral, Human - pathology ; Humans ; Immunohistochemistry ; Intercellular Signaling Peptides and Proteins - metabolism ; Liver Cancer ; Liver Neoplasms - metabolism ; Liver Neoplasms - pathology ; Male ; Middle Aged ; Retrospective Studies ; Signal Transduction - physiology ; Trans-Activators - metabolism ; Wnt Proteins ; β-蛋白酶 ; 基因表达 ; 病毒性肝炎 ; 肝细胞癌</subject><ispartof>World journal of gastroenterology : WJG, 2005-04, Vol.11 (16), p.2398-2401</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><rights>2005 Baishideng Publishing Group Inc. All rights reserved. 2005</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-b284f69ec70b21c4dcd6974738b83fa575717c8a8dd0c80c3b2b9d5ea3718fc63</citedby><cites>FETCH-LOGICAL-c450t-b284f69ec70b21c4dcd6974738b83fa575717c8a8dd0c80c3b2b9d5ea3718fc63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84123X/84123X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4305624/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4305624/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15832407$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tien, Liem Thanh</creatorcontrib><creatorcontrib>Ito, Masahiro</creatorcontrib><creatorcontrib>Nakao, Mikiko</creatorcontrib><creatorcontrib>Niino, Daisuke</creatorcontrib><creatorcontrib>Serik, Meirmanov</creatorcontrib><creatorcontrib>Nakashima, Masahiro</creatorcontrib><creatorcontrib>Wen, Chun-Yang</creatorcontrib><creatorcontrib>Yatsuhashi, Hiroshi</creatorcontrib><creatorcontrib>Ishibashi, Hiromi</creatorcontrib><title>Expression of β-catenin in hepatocellular carcinoma</title><title>World journal of gastroenterology : WJG</title><addtitle>World Journal of Gastroenterology</addtitle><description>AIM: The β-catenin has been recognized as a critical member of the Wnt signaling pathway and plays an important role in the generation/differentiation of many tissues. Inappropriate activation of this pathway has been implicated in carcinogenesis. The mechanism underlying the development as well as its prognosis of hepatocellular carcinoma (HCC) has remained unclear. The purpose of this study is to analyze the expression of β-catenin in HCC in relation to histological grades and viral hepatitis backgrounds. METHODS: Thirty-two sections were selected at random from autopsy and surgical cases of HCC. Immuohistologically, the location and positivity of β-catenin expression in HCC was examined. RESULTS: Normal hepatocytes did not express β-catenin. In 78% of HCC β-catenin was expressed at the membrane of the cells, with or without cytoplasmic and/or nuclear expression. The tumor cells with well- and moderately-differentiated grades expressed frequently at the membrane and cytoplasm compared with poorly-differentiated type. Nuclear expression of β-catenin was prone to occur in the tumor cells of poorly-differentiated grade. There were 15% of hepatitis C virus (HCV) backgrounds with nuclear expression. In contrast, there was 38% with nuclear expression in hepatitis B virus (HBV) backgrounds. In nonBnonC hepatitis, no case expressed nuclear β-catenin. CONCLUSION: The β-catenin expression in HCC cells was heterogenous among types of hepatitis viral infection. Wnt signaling pathway might be deeply involved in less-differentiated HCC and HBV background.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>beta Catenin</subject><subject>Carcinoma, Hepatocellular - metabolism</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Cytoskeletal Proteins - metabolism</subject><subject>Female</subject><subject>Hepatitis, Viral, Human - metabolism</subject><subject>Hepatitis, Viral, Human - pathology</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Intercellular Signaling Peptides and Proteins - metabolism</subject><subject>Liver Cancer</subject><subject>Liver Neoplasms - metabolism</subject><subject>Liver Neoplasms - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Retrospective Studies</subject><subject>Signal Transduction - physiology</subject><subject>Trans-Activators - metabolism</subject><subject>Wnt Proteins</subject><subject>β-蛋白酶</subject><subject>基因表达</subject><subject>病毒性肝炎</subject><subject>肝细胞癌</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkMtKAzEUhoMotlb3rqSI26knt0lmI0ipFyi40XXIZDJt6jSpmV70tXwQn8mUFi8QOIt85z8_H0LnGAZUMHm9mU0Ga4wHDucDQgt5gLqE4CIjksEh6mIAkRWUiA46adsZAKGUk2PUwVxSwkB0ERu9L6JtWxd8P9T9r8_M6KX1zvfTm9qFXgZjm2bV6Ng3Ohrnw1yfoqNaN609288eerkbPQ8fsvHT_ePwdpwZxmGZlalGnRfWCCgJNqwyVV4IJqgsJa01F1xgYaSWVQVGgqElKYuKW00FlrXJaQ_d7HIXq3JuK2P9MupGLaKb6_ihgnbq_493UzUJa8Uo8JywFHC1C9hoX2s_UbOwij5VVskcAeA4B9hisMNMDG0bbf1zAoPait7iKolWSbTaik4rF3-r_S7szSbgcp85DX7y5tLxUpvX2jU2QbzIZYK-AXNih00</recordid><startdate>20050428</startdate><enddate>20050428</enddate><creator>Tien, Liem Thanh</creator><creator>Ito, Masahiro</creator><creator>Nakao, Mikiko</creator><creator>Niino, Daisuke</creator><creator>Serik, Meirmanov</creator><creator>Nakashima, Masahiro</creator><creator>Wen, Chun-Yang</creator><creator>Yatsuhashi, Hiroshi</creator><creator>Ishibashi, Hiromi</creator><general>Department of Pathology, National Nagasaki Medical Center, 2-1001-1 Kubara,Omura, Nagasaki 856-8562, Japan%Department of Molecular Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Science, 1-12-4 Sakamoto,Nagasaki 852-8523, Japan%Tissue and Histopathology Section Division of Scientific Data Registry, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Science, 1-12-4 Sakamoto,Nagasaki 852-8523, Japan%Department of Molecular Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Science, 1-12-4 Sakamoto,Nagasaki 852-8523, Japan</general><general>Department of Digestive Disease, Nanjing Drum Tower Hospital, Medical School of Nanjing University, Nanjing 210008, Jiangsu Province, China%Clinical Research Center,National Nagasaki Medical Center, 2-1001-1 Kubara, Omura,Nagasaki 856-8562, Japan</general><general>Baishideng Publishing Group Inc</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope><scope>5PM</scope></search><sort><creationdate>20050428</creationdate><title>Expression of β-catenin in hepatocellular carcinoma</title><author>Tien, Liem Thanh ; 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Inappropriate activation of this pathway has been implicated in carcinogenesis. The mechanism underlying the development as well as its prognosis of hepatocellular carcinoma (HCC) has remained unclear. The purpose of this study is to analyze the expression of β-catenin in HCC in relation to histological grades and viral hepatitis backgrounds. METHODS: Thirty-two sections were selected at random from autopsy and surgical cases of HCC. Immuohistologically, the location and positivity of β-catenin expression in HCC was examined. RESULTS: Normal hepatocytes did not express β-catenin. In 78% of HCC β-catenin was expressed at the membrane of the cells, with or without cytoplasmic and/or nuclear expression. The tumor cells with well- and moderately-differentiated grades expressed frequently at the membrane and cytoplasm compared with poorly-differentiated type. Nuclear expression of β-catenin was prone to occur in the tumor cells of poorly-differentiated grade. There were 15% of hepatitis C virus (HCV) backgrounds with nuclear expression. In contrast, there was 38% with nuclear expression in hepatitis B virus (HBV) backgrounds. In nonBnonC hepatitis, no case expressed nuclear β-catenin. CONCLUSION: The β-catenin expression in HCC cells was heterogenous among types of hepatitis viral infection. Wnt signaling pathway might be deeply involved in less-differentiated HCC and HBV background.</abstract><cop>United States</cop><pub>Department of Pathology, National Nagasaki Medical Center, 2-1001-1 Kubara,Omura, Nagasaki 856-8562, Japan%Department of Molecular Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Science, 1-12-4 Sakamoto,Nagasaki 852-8523, Japan%Tissue and Histopathology Section Division of Scientific Data Registry, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Science, 1-12-4 Sakamoto,Nagasaki 852-8523, Japan%Department of Molecular Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Science, 1-12-4 Sakamoto,Nagasaki 852-8523, Japan</pub><pmid>15832407</pmid><doi>10.3748/wjg.v11.i16.2398</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over beta Catenin Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cytoskeletal Proteins - metabolism Female Hepatitis, Viral, Human - metabolism Hepatitis, Viral, Human - pathology Humans Immunohistochemistry Intercellular Signaling Peptides and Proteins - metabolism Liver Cancer Liver Neoplasms - metabolism Liver Neoplasms - pathology Male Middle Aged Retrospective Studies Signal Transduction - physiology Trans-Activators - metabolism Wnt Proteins β-蛋白酶 基因表达 病毒性肝炎 肝细胞癌 |
| title | Expression of β-catenin in hepatocellular carcinoma |
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