A Combined Proteomics/Genomics Approach Links Hepatitis C Virus Infection with Nonsense-Mediated mRNA Decay

Hepatitis C virus (HCV) is a leading cause of liver disease, but insight into virus-host interactions remains limited. We systematically used affinity purification/mass spectrometry to define the host interactions of all ten HCV proteins in hepatoma cells. We combined these studies with RNAi knockdo...

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Veröffentlicht in:	Molecular cell 2015-01, Vol.57 (2), p.329-340
Hauptverfasser:	Ramage, Holly R., Kumar, G. Renuka, Verschueren, Erik, Johnson, Jeffrey R., Von Dollen, John, Johnson, Tasha, Newton, Billy, Shah, Priya, Horner, Julie, Krogan, Nevan J., Ott, Melanie
Format:	Artikel
Sprache:	eng
Schlagworte:	Carrier Proteins - metabolism Cell Line, Tumor genes genomics Hepacivirus - physiology Hepatitis C - metabolism Hepatitis C - virology Hepatitis C virus hepatoma Host-Pathogen Interactions host-pathogen relationships Humans mass spectrometry messenger RNA mitochondria Mitochondria - metabolism Mitochondrial Proteins - metabolism monitoring Nonsense Mediated mRNA Decay Protein Interaction Maps Protein Transport protein-protein interactions proteins Proteome - metabolism Proteomics RNA interference Vesicular Transport Proteins - metabolism Viral Core Proteins - metabolism Viral Nonstructural Proteins - metabolism
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