Two miRNA Clusters Reveal Alternative Paths in Late-Stage Reprogramming

Ectopic expression of specific factors such as Oct4, Sox2, and Klf4 (OSK) is sufficient to reprogram somatic cells into induced pluripotent stem cells (iPSCs). In this study, we examine the paths taken by cells during the reprogramming process by following the transcriptional activation of two pluri...

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Veröffentlicht in:	Cell stem cell 2014-05, Vol.14 (5), p.617-631
Hauptverfasser:	Parchem, Ronald J., Ye, Julia, Judson, Robert L., LaRussa, Marie F., Krishnakumar, Raga, Blelloch, Amy, Oldham, Michael C., Blelloch, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cellular Reprogramming - genetics Cellular Reprogramming - physiology DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Female Male Mice MicroRNAs - genetics MicroRNAs - metabolism Transcription Factors - genetics Transcription Factors - metabolism
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