Understanding the Roles of FAK in Cancer: Inhibitors, Genetic Models, and New Insights

Focal adhesion kinase (FAK) is a protein tyrosine kinase that regulates cellular adhesion, motility, proliferation and survival in various types of cells. Interestingly, FAK is activated and/or overexpressed in advanced cancers, and promotes cancer progression and metastasis. For this reason, FAK be...

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Veröffentlicht in:	Journal of Histochemistry & Cytochemistry 2015-02, Vol.63 (2), p.114-128
Hauptverfasser:	Yoon, Hyunho, Dehart, Joshua P., Murphy, James M., Lim, Ssang-Taek Steve
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Nucleus - enzymology Disease Models, Animal Epigenesis, Genetic Focal Adhesion Protein-Tyrosine Kinases - antagonists & inhibitors Focal Adhesion Protein-Tyrosine Kinases - chemistry Focal Adhesion Protein-Tyrosine Kinases - genetics Focal Adhesion Protein-Tyrosine Kinases - metabolism Humans Neoplasms - enzymology Neoplasms - genetics Neoplasms - pathology Protein Kinase Inhibitors - pharmacology
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