Granulocyte Collagenase: Selective Digestion of Type I Relative to Type III Collagen

Collagenases produced by human polymorphonuclear leukocytes, human lung fibroblasts, and rabbit pulmonary alveolar macrophages were compared in their ability to digest soluble native type I and type III collagens. While the fibroblast and macrophage collagenases attacked the two substrates at approx...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1977-03, Vol.74 (3), p.897-901
Hauptverfasser:	Horwitz, Allen L., Hance, Allan J., Crystal, Ronald G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Collagens Connective tissues Enzyme substrates Enzymes Fibroblasts Fibroblasts - enzymology Humans Lungs Macrophages Macrophages - enzymology Microbial Collagenase - antagonists & inhibitors Microbial Collagenase - metabolism Neutrophils Neutrophils - enzymology Rabbits Ungulates
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