Granulocyte Collagenase: Selective Digestion of Type I Relative to Type III Collagen
Collagenases produced by human polymorphonuclear leukocytes, human lung fibroblasts, and rabbit pulmonary alveolar macrophages were compared in their ability to digest soluble native type I and type III collagens. While the fibroblast and macrophage collagenases attacked the two substrates at approx...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1977-03, Vol.74 (3), p.897-901 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 74 |
| creator | Horwitz, Allen L. Hance, Allan J. Crystal, Ronald G. |
| description | Collagenases produced by human polymorphonuclear leukocytes, human lung fibroblasts, and rabbit pulmonary alveolar macrophages were compared in their ability to digest soluble native type I and type III collagens. While the fibroblast and macrophage collagenases attacked the two substrates at approximately equal rates, the leukocyte collagenase attacked type I collagen preferentially (15:1) in comparison to type III collagen. This was true with human or rabbit collagen substrates. Thus, proteolysis of collagen, particularly in acute inflammation, may have a significant role in controlling the types of collagen present in connective tissue. |
| doi_str_mv | 10.1073/pnas.74.3.897 |
| format | Article |
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While the fibroblast and macrophage collagenases attacked the two substrates at approximately equal rates, the leukocyte collagenase attacked type I collagen preferentially (15:1) in comparison to type III collagen. This was true with human or rabbit collagen substrates. Thus, proteolysis of collagen, particularly in acute inflammation, may have a significant role in controlling the types of collagen present in connective tissue.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.74.3.897</identifier><identifier>PMID: 191839</identifier><language>eng</language><publisher>United States: National Academy of Sciences of the United States of America</publisher><subject>Animals ; Collagens ; Connective tissues ; Enzyme substrates ; Enzymes ; Fibroblasts ; Fibroblasts - enzymology ; Humans ; Lungs ; Macrophages ; Macrophages - enzymology ; Microbial Collagenase - antagonists & inhibitors ; Microbial Collagenase - metabolism ; Neutrophils ; Neutrophils - enzymology ; Rabbits ; Ungulates</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1977-03, Vol.74 (3), p.897-901</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4317-30b636f3251a8b7328452beeea7e2ec47b31615f35e82cb85913ca21d13a5ee93</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/74/3.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/66306$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/66306$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,27924,27925,53791,53793,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/191839$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Horwitz, Allen L.</creatorcontrib><creatorcontrib>Hance, Allan J.</creatorcontrib><creatorcontrib>Crystal, Ronald G.</creatorcontrib><title>Granulocyte Collagenase: Selective Digestion of Type I Relative to Type III Collagen</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Collagenases produced by human polymorphonuclear leukocytes, human lung fibroblasts, and rabbit pulmonary alveolar macrophages were compared in their ability to digest soluble native type I and type III collagens. While the fibroblast and macrophage collagenases attacked the two substrates at approximately equal rates, the leukocyte collagenase attacked type I collagen preferentially (15:1) in comparison to type III collagen. This was true with human or rabbit collagen substrates. Thus, proteolysis of collagen, particularly in acute inflammation, may have a significant role in controlling the types of collagen present in connective tissue.</description><subject>Animals</subject><subject>Collagens</subject><subject>Connective tissues</subject><subject>Enzyme substrates</subject><subject>Enzymes</subject><subject>Fibroblasts</subject><subject>Fibroblasts - enzymology</subject><subject>Humans</subject><subject>Lungs</subject><subject>Macrophages</subject><subject>Macrophages - enzymology</subject><subject>Microbial Collagenase - antagonists & inhibitors</subject><subject>Microbial Collagenase - metabolism</subject><subject>Neutrophils</subject><subject>Neutrophils - enzymology</subject><subject>Rabbits</subject><subject>Ungulates</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kb1v2zAQxYmiaeq4HbsUHbS0mxySR4lUgAyB0zgGDBRInJmg6JMjgxYdUTLq_z7yR1xn6XQA3-_d8e4R8o3RAaMSLleVCQMpBjBQmfxAeoxmLE5FRj-SHqVcxkpw8ZlchLCglGaJoufkE8uYgqxHpqPaVK3zdtNgNPTOmTl2_fAqekSHtinXGN2WcwxN6avIF9F0s8JoHD2gMzux8Yen8fjo_0LOCuMCfj3UPnm6-z0d3seTP6Px8GYSWwFMxkDzFNICeMKMyiVwJRKeI6KRyNEKmQNLWVJAgorbXCUZA2s4mzEwCWIGfXK977tq8yXOLFZNbZxe1eXS1BvtTanfK1X5rOd-rQXQhLPO_-vgr_1L2-2ol2Ww2C1RoW-DVqBSKrtD9Um8B23tQ6ixOM5gVG9D0NsQtBQadBdCx_84_dg_enf1E3nrehNP3D__I-uida7Bv03Hfd9zi9D4-gimKdAUXgHIpKNa</recordid><startdate>19770301</startdate><enddate>19770301</enddate><creator>Horwitz, Allen L.</creator><creator>Hance, Allan J.</creator><creator>Crystal, Ronald G.</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19770301</creationdate><title>Granulocyte Collagenase: Selective Digestion of Type I Relative to Type III Collagen</title><author>Horwitz, Allen L. ; Hance, Allan J. ; Crystal, Ronald G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4317-30b636f3251a8b7328452beeea7e2ec47b31615f35e82cb85913ca21d13a5ee93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Animals</topic><topic>Collagens</topic><topic>Connective tissues</topic><topic>Enzyme substrates</topic><topic>Enzymes</topic><topic>Fibroblasts</topic><topic>Fibroblasts - enzymology</topic><topic>Humans</topic><topic>Lungs</topic><topic>Macrophages</topic><topic>Macrophages - enzymology</topic><topic>Microbial Collagenase - antagonists & inhibitors</topic><topic>Microbial Collagenase - metabolism</topic><topic>Neutrophils</topic><topic>Neutrophils - enzymology</topic><topic>Rabbits</topic><topic>Ungulates</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Horwitz, Allen L.</creatorcontrib><creatorcontrib>Hance, Allan J.</creatorcontrib><creatorcontrib>Crystal, Ronald G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Horwitz, Allen L.</au><au>Hance, Allan J.</au><au>Crystal, Ronald G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Granulocyte Collagenase: Selective Digestion of Type I Relative to Type III Collagen</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1977-03-01</date><risdate>1977</risdate><volume>74</volume><issue>3</issue><spage>897</spage><epage>901</epage><pages>897-901</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>Collagenases produced by human polymorphonuclear leukocytes, human lung fibroblasts, and rabbit pulmonary alveolar macrophages were compared in their ability to digest soluble native type I and type III collagens. While the fibroblast and macrophage collagenases attacked the two substrates at approximately equal rates, the leukocyte collagenase attacked type I collagen preferentially (15:1) in comparison to type III collagen. This was true with human or rabbit collagen substrates. Thus, proteolysis of collagen, particularly in acute inflammation, may have a significant role in controlling the types of collagen present in connective tissue.</abstract><cop>United States</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>191839</pmid><doi>10.1073/pnas.74.3.897</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1977-03, Vol.74 (3), p.897-901 |
| issn | 0027-8424 1091-6490 |
| language | eng |
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| source | MEDLINE; Full-Text Journals in Chemistry (Open access); PubMed Central; Alma/SFX Local Collection; JSTOR |
| subjects | Animals Collagens Connective tissues Enzyme substrates Enzymes Fibroblasts Fibroblasts - enzymology Humans Lungs Macrophages Macrophages - enzymology Microbial Collagenase - antagonists & inhibitors Microbial Collagenase - metabolism Neutrophils Neutrophils - enzymology Rabbits Ungulates |
| title | Granulocyte Collagenase: Selective Digestion of Type I Relative to Type III Collagen |
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