Identification and characterization of novel factors that act in the nonsense-mediated mRNA decay pathway in nematodes, flies and mammals

Nonsense‐mediated mRNA decay (NMD) is a surveillance mechanism that degrades mRNAs harboring premature termination codons (PTCs). We have conducted a genome‐wide RNAi screen in Caenorhabditis elegans that resulted in the identification of five novel NMD genes that are conserved throughout evolution....

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Veröffentlicht in:	EMBO reports 2015-01, Vol.16 (1), p.71-78
Hauptverfasser:	Casadio, Angela, Longman, Dasa, Hug, Nele, Delavaine, Laurent, Vallejos Baier, Raúl, Alonso, Claudio R, Cáceres, Javier F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified C. elegans Caenorhabditis elegans - genetics Caenorhabditis elegans - growth & development Caenorhabditis elegans - metabolism Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Carrier Proteins - genetics Carrier Proteins - metabolism Decay Drosophila melanogaster - embryology Drosophila melanogaster - genetics Drosophila Proteins - genetics Drosophila Proteins - metabolism Egg Proteins - genetics Egg Proteins - metabolism EMBO36 Embryo, Nonmammalian Evolution Evolution, Molecular Fruits Gene Knockdown Techniques Genomics GTP-Binding Proteins - genetics GTP-Binding Proteins - metabolism HeLa Cells Humans Insects Microfilament Proteins - genetics Microfilament Proteins - metabolism Nematodes Nonsense Mediated mRNA Decay - physiology nonsense-mediated decay Nuclear Proteins - genetics Nuclear Proteins - metabolism Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Ribonucleic acid RNA RNA Interference RNAi screen Scientific Report Scientific Reports smg genes
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