Identification and characterization of novel factors that act in the nonsense-mediated mRNA decay pathway in nematodes, flies and mammals
Nonsense‐mediated mRNA decay (NMD) is a surveillance mechanism that degrades mRNAs harboring premature termination codons (PTCs). We have conducted a genome‐wide RNAi screen in Caenorhabditis elegans that resulted in the identification of five novel NMD genes that are conserved throughout evolution....
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| creator | Casadio, Angela Longman, Dasa Hug, Nele Delavaine, Laurent Vallejos Baier, Raúl Alonso, Claudio R Cáceres, Javier F |
| description | Nonsense‐mediated mRNA decay (NMD) is a surveillance mechanism that degrades mRNAs harboring premature termination codons (PTCs). We have conducted a genome‐wide RNAi screen in
Caenorhabditis elegans
that resulted in the identification of five novel NMD genes that are conserved throughout evolution. Two of their human homologs,
GNL2
(
ngp‐1
) and
SEC13
(
npp‐20
), are also required for NMD in human cells. We also show that the
C. elegans
gene
noah‐2
, which is present in
Drosophila melanogaster
but absent in humans, is an NMD factor in fruit flies. Altogether, these data identify novel NMD factors that are conserved throughout evolution, highlighting the complexity of the NMD pathway and suggesting that yet uncovered novel factors may act to regulate this process.
Synopsis
A genome‐wide RNAi screen in
C. elegans
identifies five novel NMD genes that are required for development and conserved throughout evolution, suggesting that the regulation of the NMD pathway is more complex than previously thought.
Five novel NMD factors that are also essential for development are identified in
C. elegans
.
Two of the human orthologs,
GNL2
(
ngp‐1
) and
SEC13
(
npp‐20
), are also required for NMD in human cells.
The
C. elegans
gene
noah‐2
, which is present in
Drosophila melanogaster
but absent in humans, is a tissue‐specific NMD factor in fruit flies.
Graphical Abstract
A genome‐wide RNAi screen in
C. elegans
identifies five novel NMD genes that are required for development and conserved throughout evolution, suggesting that the regulation of the NMD pathway is more complex than previously thought. |
| doi_str_mv | 10.15252/embr.201439183 |
| format | Article |
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Caenorhabditis elegans
that resulted in the identification of five novel NMD genes that are conserved throughout evolution. Two of their human homologs,
GNL2
(
ngp‐1
) and
SEC13
(
npp‐20
), are also required for NMD in human cells. We also show that the
C. elegans
gene
noah‐2
, which is present in
Drosophila melanogaster
but absent in humans, is an NMD factor in fruit flies. Altogether, these data identify novel NMD factors that are conserved throughout evolution, highlighting the complexity of the NMD pathway and suggesting that yet uncovered novel factors may act to regulate this process.
Synopsis
A genome‐wide RNAi screen in
C. elegans
identifies five novel NMD genes that are required for development and conserved throughout evolution, suggesting that the regulation of the NMD pathway is more complex than previously thought.
Five novel NMD factors that are also essential for development are identified in
C. elegans
.
Two of the human orthologs,
GNL2
(
ngp‐1
) and
SEC13
(
npp‐20
), are also required for NMD in human cells.
The
C. elegans
gene
noah‐2
, which is present in
Drosophila melanogaster
but absent in humans, is a tissue‐specific NMD factor in fruit flies.
Graphical Abstract
A genome‐wide RNAi screen in
C. elegans
identifies five novel NMD genes that are required for development and conserved throughout evolution, suggesting that the regulation of the NMD pathway is more complex than previously thought.</description><identifier>ISSN: 1469-221X</identifier><identifier>EISSN: 1469-3178</identifier><identifier>DOI: 10.15252/embr.201439183</identifier><identifier>PMID: 25452588</identifier><identifier>CODEN: ERMEAX</identifier><language>eng</language><publisher>London: Blackwell Publishing Ltd</publisher><subject>Animals ; Animals, Genetically Modified ; C. elegans ; Caenorhabditis elegans - genetics ; Caenorhabditis elegans - growth & development ; Caenorhabditis elegans - metabolism ; Caenorhabditis elegans Proteins - genetics ; Caenorhabditis elegans Proteins - metabolism ; Carrier Proteins - genetics ; Carrier Proteins - metabolism ; Decay ; Drosophila melanogaster - embryology ; Drosophila melanogaster - genetics ; Drosophila Proteins - genetics ; Drosophila Proteins - metabolism ; Egg Proteins - genetics ; Egg Proteins - metabolism ; EMBO36 ; Embryo, Nonmammalian ; Evolution ; Evolution, Molecular ; Fruits ; Gene Knockdown Techniques ; Genomics ; GTP-Binding Proteins - genetics ; GTP-Binding Proteins - metabolism ; HeLa Cells ; Humans ; Insects ; Microfilament Proteins - genetics ; Microfilament Proteins - metabolism ; Nematodes ; Nonsense Mediated mRNA Decay - physiology ; nonsense-mediated decay ; Nuclear Proteins - genetics ; Nuclear Proteins - metabolism ; Recombinant Fusion Proteins - genetics ; Recombinant Fusion Proteins - metabolism ; Ribonucleic acid ; RNA ; RNA Interference ; RNAi screen ; Scientific Report ; Scientific Reports ; smg genes</subject><ispartof>EMBO reports, 2015-01, Vol.16 (1), p.71-78</ispartof><rights>The Authors. Published under the terms of the CC BY 4.0 license 2014</rights><rights>2014 The Authors. Published under the terms of the CC BY 4.0 license</rights><rights>2014 The Authors. Published under the terms of the CC BY 4.0 license.</rights><rights>2015 EMBO</rights><rights>2014 The Authors. Published under the terms of the CC BY 4.0 license 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6213-af46ba4477954cd9acd46c2e83da8988a53fbe0e809c01562b3ce582580781e33</citedby><cites>FETCH-LOGICAL-c6213-af46ba4477954cd9acd46c2e83da8988a53fbe0e809c01562b3ce582580781e33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304730/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304730/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,1427,27901,27902,41096,42165,45550,45551,46384,46808,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25452588$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Casadio, Angela</creatorcontrib><creatorcontrib>Longman, Dasa</creatorcontrib><creatorcontrib>Hug, Nele</creatorcontrib><creatorcontrib>Delavaine, Laurent</creatorcontrib><creatorcontrib>Vallejos Baier, Raúl</creatorcontrib><creatorcontrib>Alonso, Claudio R</creatorcontrib><creatorcontrib>Cáceres, Javier F</creatorcontrib><title>Identification and characterization of novel factors that act in the nonsense-mediated mRNA decay pathway in nematodes, flies and mammals</title><title>EMBO reports</title><addtitle>EMBO Rep</addtitle><addtitle>EMBO rep</addtitle><description>Nonsense‐mediated mRNA decay (NMD) is a surveillance mechanism that degrades mRNAs harboring premature termination codons (PTCs). We have conducted a genome‐wide RNAi screen in
Caenorhabditis elegans
that resulted in the identification of five novel NMD genes that are conserved throughout evolution. Two of their human homologs,
GNL2
(
ngp‐1
) and
SEC13
(
npp‐20
), are also required for NMD in human cells. We also show that the
C. elegans
gene
noah‐2
, which is present in
Drosophila melanogaster
but absent in humans, is an NMD factor in fruit flies. Altogether, these data identify novel NMD factors that are conserved throughout evolution, highlighting the complexity of the NMD pathway and suggesting that yet uncovered novel factors may act to regulate this process.
Synopsis
A genome‐wide RNAi screen in
C. elegans
identifies five novel NMD genes that are required for development and conserved throughout evolution, suggesting that the regulation of the NMD pathway is more complex than previously thought.
Five novel NMD factors that are also essential for development are identified in
C. elegans
.
Two of the human orthologs,
GNL2
(
ngp‐1
) and
SEC13
(
npp‐20
), are also required for NMD in human cells.
The
C. elegans
gene
noah‐2
, which is present in
Drosophila melanogaster
but absent in humans, is a tissue‐specific NMD factor in fruit flies.
Graphical Abstract
A genome‐wide RNAi screen in
C. elegans
identifies five novel NMD genes that are required for development and conserved throughout evolution, suggesting that the regulation of the NMD pathway is more complex than previously thought.</description><subject>Animals</subject><subject>Animals, Genetically Modified</subject><subject>C. elegans</subject><subject>Caenorhabditis elegans - genetics</subject><subject>Caenorhabditis elegans - growth & development</subject><subject>Caenorhabditis elegans - metabolism</subject><subject>Caenorhabditis elegans Proteins - genetics</subject><subject>Caenorhabditis elegans Proteins - metabolism</subject><subject>Carrier Proteins - genetics</subject><subject>Carrier Proteins - metabolism</subject><subject>Decay</subject><subject>Drosophila melanogaster - embryology</subject><subject>Drosophila melanogaster - genetics</subject><subject>Drosophila Proteins - genetics</subject><subject>Drosophila Proteins - metabolism</subject><subject>Egg Proteins - genetics</subject><subject>Egg Proteins - metabolism</subject><subject>EMBO36</subject><subject>Embryo, Nonmammalian</subject><subject>Evolution</subject><subject>Evolution, Molecular</subject><subject>Fruits</subject><subject>Gene Knockdown Techniques</subject><subject>Genomics</subject><subject>GTP-Binding Proteins - genetics</subject><subject>GTP-Binding Proteins - metabolism</subject><subject>HeLa Cells</subject><subject>Humans</subject><subject>Insects</subject><subject>Microfilament Proteins - genetics</subject><subject>Microfilament Proteins - metabolism</subject><subject>Nematodes</subject><subject>Nonsense Mediated mRNA Decay - physiology</subject><subject>nonsense-mediated decay</subject><subject>Nuclear Proteins - genetics</subject><subject>Nuclear Proteins - metabolism</subject><subject>Recombinant Fusion Proteins - genetics</subject><subject>Recombinant Fusion Proteins - metabolism</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>RNA Interference</subject><subject>RNAi screen</subject><subject>Scientific Report</subject><subject>Scientific Reports</subject><subject>smg genes</subject><issn>1469-221X</issn><issn>1469-3178</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhiMEoh9w5oYsceFAWn8lcThUKlVbKi1FtCC4WbPOpOuS2IudbVn-Af8at1lWCxJCsjQj-3nfmfFk2TNG91jBC76P_TTsccqkqJkSD7JtJss6F6xSD1c55-zLVrYT4zWltKgr9Tjb4oVMaqW2s59nDbrBttbAYL0j4BpiZhDADBjsj_HSt8T5G-xIm659iGSYwUBSTqxLOaZXFzGdvMfGwoAN6S_OD0mDBpZkDsPsNsXEOuxh8A3GV6TtLMb7cj30PXTxSfaoTQGfruJu9unk-OPR23zy_vTs6HCSm5IzkUMryylIWVV1IU1Tg2lkaTgq0YCqlYJCtFOkqGhtKCtKPhUGC5WmpZViKMRudjD6zhfT1K5J4wfo9DzYHsJSe7D6zxdnZ_rK32gpqKwETQYvVwbBf1tgHHRvo8GuA4d-ETUrpUg_LxhL6Iu_0Gu_CC6Nd0dxSkXJ60Ttj5QJPsaA7boZRvX9mvXdmvV6zUnxfHOGNf97rwl4PQK3tsPl__z08bs3F5vudBTHpHNXGDa6_mdD-SixccDv63oQvuqyElWhP5-f6smHalJNLi-1Er8AsRHWCQ</recordid><startdate>201501</startdate><enddate>201501</enddate><creator>Casadio, Angela</creator><creator>Longman, Dasa</creator><creator>Hug, Nele</creator><creator>Delavaine, Laurent</creator><creator>Vallejos Baier, Raúl</creator><creator>Alonso, Claudio R</creator><creator>Cáceres, Javier F</creator><general>Blackwell Publishing Ltd</general><general>Nature Publishing Group UK</general><general>Springer Nature B.V</general><general>BlackWell Publishing Ltd</general><scope>BSCLL</scope><scope>C6C</scope><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201501</creationdate><title>Identification and characterization of novel factors that act in the nonsense-mediated mRNA decay pathway in nematodes, flies and mammals</title><author>Casadio, Angela ; Longman, Dasa ; Hug, Nele ; Delavaine, Laurent ; Vallejos Baier, Raúl ; Alonso, Claudio R ; Cáceres, Javier F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6213-af46ba4477954cd9acd46c2e83da8988a53fbe0e809c01562b3ce582580781e33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Animals, Genetically Modified</topic><topic>C. elegans</topic><topic>Caenorhabditis elegans - genetics</topic><topic>Caenorhabditis elegans - growth & development</topic><topic>Caenorhabditis elegans - metabolism</topic><topic>Caenorhabditis elegans Proteins - genetics</topic><topic>Caenorhabditis elegans Proteins - metabolism</topic><topic>Carrier Proteins - genetics</topic><topic>Carrier Proteins - metabolism</topic><topic>Decay</topic><topic>Drosophila melanogaster - embryology</topic><topic>Drosophila melanogaster - genetics</topic><topic>Drosophila Proteins - genetics</topic><topic>Drosophila Proteins - metabolism</topic><topic>Egg Proteins - genetics</topic><topic>Egg Proteins - metabolism</topic><topic>EMBO36</topic><topic>Embryo, Nonmammalian</topic><topic>Evolution</topic><topic>Evolution, Molecular</topic><topic>Fruits</topic><topic>Gene Knockdown Techniques</topic><topic>Genomics</topic><topic>GTP-Binding Proteins - genetics</topic><topic>GTP-Binding Proteins - metabolism</topic><topic>HeLa Cells</topic><topic>Humans</topic><topic>Insects</topic><topic>Microfilament Proteins - genetics</topic><topic>Microfilament Proteins - metabolism</topic><topic>Nematodes</topic><topic>Nonsense Mediated mRNA Decay - physiology</topic><topic>nonsense-mediated decay</topic><topic>Nuclear Proteins - genetics</topic><topic>Nuclear Proteins - metabolism</topic><topic>Recombinant Fusion Proteins - genetics</topic><topic>Recombinant Fusion Proteins - metabolism</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>RNA Interference</topic><topic>RNAi screen</topic><topic>Scientific Report</topic><topic>Scientific Reports</topic><topic>smg genes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Casadio, Angela</creatorcontrib><creatorcontrib>Longman, Dasa</creatorcontrib><creatorcontrib>Hug, Nele</creatorcontrib><creatorcontrib>Delavaine, Laurent</creatorcontrib><creatorcontrib>Vallejos Baier, Raúl</creatorcontrib><creatorcontrib>Alonso, Claudio R</creatorcontrib><creatorcontrib>Cáceres, Javier F</creatorcontrib><collection>Istex</collection><collection>Springer Nature OA Free Journals</collection><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>EMBO reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Casadio, Angela</au><au>Longman, Dasa</au><au>Hug, Nele</au><au>Delavaine, Laurent</au><au>Vallejos Baier, Raúl</au><au>Alonso, Claudio R</au><au>Cáceres, Javier F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identification and characterization of novel factors that act in the nonsense-mediated mRNA decay pathway in nematodes, flies and mammals</atitle><jtitle>EMBO reports</jtitle><stitle>EMBO Rep</stitle><addtitle>EMBO rep</addtitle><date>2015-01</date><risdate>2015</risdate><volume>16</volume><issue>1</issue><spage>71</spage><epage>78</epage><pages>71-78</pages><issn>1469-221X</issn><eissn>1469-3178</eissn><coden>ERMEAX</coden><abstract>Nonsense‐mediated mRNA decay (NMD) is a surveillance mechanism that degrades mRNAs harboring premature termination codons (PTCs). We have conducted a genome‐wide RNAi screen in
Caenorhabditis elegans
that resulted in the identification of five novel NMD genes that are conserved throughout evolution. Two of their human homologs,
GNL2
(
ngp‐1
) and
SEC13
(
npp‐20
), are also required for NMD in human cells. We also show that the
C. elegans
gene
noah‐2
, which is present in
Drosophila melanogaster
but absent in humans, is an NMD factor in fruit flies. Altogether, these data identify novel NMD factors that are conserved throughout evolution, highlighting the complexity of the NMD pathway and suggesting that yet uncovered novel factors may act to regulate this process.
Synopsis
A genome‐wide RNAi screen in
C. elegans
identifies five novel NMD genes that are required for development and conserved throughout evolution, suggesting that the regulation of the NMD pathway is more complex than previously thought.
Five novel NMD factors that are also essential for development are identified in
C. elegans
.
Two of the human orthologs,
GNL2
(
ngp‐1
) and
SEC13
(
npp‐20
), are also required for NMD in human cells.
The
C. elegans
gene
noah‐2
, which is present in
Drosophila melanogaster
but absent in humans, is a tissue‐specific NMD factor in fruit flies.
Graphical Abstract
A genome‐wide RNAi screen in
C. elegans
identifies five novel NMD genes that are required for development and conserved throughout evolution, suggesting that the regulation of the NMD pathway is more complex than previously thought.</abstract><cop>London</cop><pub>Blackwell Publishing Ltd</pub><pmid>25452588</pmid><doi>10.15252/embr.201439183</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1469-221X |
| ispartof | EMBO reports, 2015-01, Vol.16 (1), p.71-78 |
| issn | 1469-221X 1469-3178 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4304730 |
| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete; EZB-FREE-00999 freely available EZB journals; PubMed Central; Springer Nature OA Free Journals |
| subjects | Animals Animals, Genetically Modified C. elegans Caenorhabditis elegans - genetics Caenorhabditis elegans - growth & development Caenorhabditis elegans - metabolism Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Carrier Proteins - genetics Carrier Proteins - metabolism Decay Drosophila melanogaster - embryology Drosophila melanogaster - genetics Drosophila Proteins - genetics Drosophila Proteins - metabolism Egg Proteins - genetics Egg Proteins - metabolism EMBO36 Embryo, Nonmammalian Evolution Evolution, Molecular Fruits Gene Knockdown Techniques Genomics GTP-Binding Proteins - genetics GTP-Binding Proteins - metabolism HeLa Cells Humans Insects Microfilament Proteins - genetics Microfilament Proteins - metabolism Nematodes Nonsense Mediated mRNA Decay - physiology nonsense-mediated decay Nuclear Proteins - genetics Nuclear Proteins - metabolism Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Ribonucleic acid RNA RNA Interference RNAi screen Scientific Report Scientific Reports smg genes |
| title | Identification and characterization of novel factors that act in the nonsense-mediated mRNA decay pathway in nematodes, flies and mammals |
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