Direct interaction between Id1 and Zrf1 controls neural differentiation of embryonic stem cells

Id proteins are dominant‐negative regulators within the HLH family of proteins. In embryonic stem cells (ESCs), Id1 and Id3 maintain the pluripotent state by preventing neural differentiation. The Id1‐interacting protein Zrf1 plays a crucial role as a chromatin‐bound factor in specification of the n...

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Veröffentlicht in:	EMBO reports 2015-01, Vol.16 (1), p.63-70
Hauptverfasser:	Aloia, Luigi, Gutierrez, Arantxa, Caballero, Juan Martin, Di Croce, Luciano
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation Cells, Cultured Chromatin Chromatin - metabolism Chromatin Immunoprecipitation DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism EMBO27 EMBO39 Embryonic Stem Cells - cytology Embryonic Stem Cells - physiology epigenetics Gene expression Gene Expression Regulation, Developmental Gene Knockdown Techniques Humans Id1 Inhibitor of Differentiation Protein 1 - genetics Inhibitor of Differentiation Protein 1 - metabolism Mice Molecular Chaperones neural development Neurons - cytology Oncogene Proteins - genetics Oncogene Proteins - metabolism Polycomb Polycomb-Group Proteins - genetics Polycomb-Group Proteins - metabolism Proteins RNA-Binding Proteins Scientific Report Scientific Reports Stem cells Transgenes
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