Clinicopathological characteristics and prognostic factors in combined hepatocellular carcinoma and cholangiocarcinoma

Clinicopathological characteristics and prognostic factors in combined hepatocellular carcinoma and cholangiocarcinoma

Combined hepatocellular carcinoma and cholangiocarcinoma (cHCC-CC) is an uncommon subtype of primary liver cancer that has rarely been reported in detail. This study was performed in order to evaluate the clinicopathological characteristics and prognostic factors of cHCC-CC in single center. The cli...

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Veröffentlicht in:Korean Journal of Hepato-Biliary-Pancreatic Surgery 2013-11, Vol.17 (4), p.152-156
Hauptverfasser: Park, Sang Eun, Lee, Sung Ha, Yang, Jae Do, Hwang, Hong Pil, Hwang, Si Eun, Yu, Hee Chul, Moon, Woo Sung, Cho, Baik Hwan
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container_end_page 156
container_issue 4
container_start_page 152
container_title Korean Journal of Hepato-Biliary-Pancreatic Surgery
container_volume 17
creator Park, Sang Eun
Lee, Sung Ha
Yang, Jae Do
Hwang, Hong Pil
Hwang, Si Eun
Yu, Hee Chul
Moon, Woo Sung
Cho, Baik Hwan
description Combined hepatocellular carcinoma and cholangiocarcinoma (cHCC-CC) is an uncommon subtype of primary liver cancer that has rarely been reported in detail. This study was performed in order to evaluate the clinicopathological characteristics and prognostic factors of cHCC-CC in single center. The clinicopathological features of patients diagnosed and operated with cHCC-CC at Chonbuk National Hospital between July 1998 and July 2007 were retrospectively studied by comparing them with patients with only hepatocellular carcinoma (HCC) who had undergone a hepatic resection during the same period. Ten out of 152 patients who had undergone a hepatic resection were diagnosed with cHCC-CC and thus included in this study (M : F=8 : 2, median age: 52±11.1 years). According to the parameters of the 7th American Joint Committee on Cancer T staging, there were 76 (50.0%), 44 (28.9%), 9 (5.9%), 18 (11.8%) and 5 (3.3%) patients with T stages 1, 2, 3a, 3b and 4, respectively. The overall survival period was longer in the HCC only group (68±40.4 months) than in the combined cHCC-CC group (23±40.1 months) (p
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This study was performed in order to evaluate the clinicopathological characteristics and prognostic factors of cHCC-CC in single center. The clinicopathological features of patients diagnosed and operated with cHCC-CC at Chonbuk National Hospital between July 1998 and July 2007 were retrospectively studied by comparing them with patients with only hepatocellular carcinoma (HCC) who had undergone a hepatic resection during the same period. Ten out of 152 patients who had undergone a hepatic resection were diagnosed with cHCC-CC and thus included in this study (M : F=8 : 2, median age: 52±11.1 years). According to the parameters of the 7th American Joint Committee on Cancer T staging, there were 76 (50.0%), 44 (28.9%), 9 (5.9%), 18 (11.8%) and 5 (3.3%) patients with T stages 1, 2, 3a, 3b and 4, respectively. The overall survival period was longer in the HCC only group (68±40.4 months) than in the combined cHCC-CC group (23±40.1 months) (p&lt;0.0001). The 5-year survival rate was 10% in the cHCC-CC group and 60% in the HCC group (p&lt;0.0001). The disease free survival for patients with cHCC-HCC and HCC were 16±37.4 and 51±44.3 months, respectively (p&lt;0.0001). Univariate analysis revealed that age, gender, transarterial chemoembolization (TACE), and T stage were statistically significant in terms of patient's overall survival. However, there were no significant clinicopathological factors identified by the multivariate analysis. 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The 5-year survival rate was 10% in the cHCC-CC group and 60% in the HCC group (p&lt;0.0001). The disease free survival for patients with cHCC-HCC and HCC were 16±37.4 and 51±44.3 months, respectively (p&lt;0.0001). Univariate analysis revealed that age, gender, transarterial chemoembolization (TACE), and T stage were statistically significant in terms of patient's overall survival. However, there were no significant clinicopathological factors identified by the multivariate analysis. 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title Clinicopathological characteristics and prognostic factors in combined hepatocellular carcinoma and cholangiocarcinoma
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