Modulation of Cox‐1, 5‐, 12‐ and 15‐Lox by Popular Herbal Remedies Used in Southern Italy Against Psoriasis and Other Skin Diseases

Acanthus mollis (Acanthaceae), Achillea ligustica, Artemisia arborescens and Inula viscosa (Asteraceae) are used in Southern Italy against psoriasis and other skin diseases that occur with an imbalanced production of eicosanoids. We here assessed their in vitro effects upon 5‐, 12‐, 15‐LOX and COX‐1...

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Veröffentlicht in:	Phytotherapy research 2015-01, Vol.29 (1), p.108-113
Hauptverfasser:	Bader, Ammar, Martini, Francesca, Schinella, Guillermo R, Rios, Jose L, Prieto, Jose M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acanthaceae Acanthaceae - chemistry Acanthus mollis Achillea Achillea - chemistry Animals anti-inflammatory activity Anti-Inflammatory Agents - pharmacology Arachidonate Lipoxygenases - metabolism Artemisia Artemisia - chemistry Asteraceae biosynthesis Blood Platelets - drug effects Cyclooxygenase 1 - metabolism Dermatologic Agents - pharmacology Dittrichia viscosa eicosanoids enzymes ethyl acetate free radical scavengers HeLa Cells herbal medicine herbal medicines hexane Humans ingredients inhibitory concentration 50 Inula - chemistry Italy Leukocytes - drug effects leukotrienes methanol methylene chloride NF-kappa B - metabolism Phytotherapy Plant Extracts - pharmacology Plants, Medicinal - chemistry prostaglandins psoriasis Psoriasis - drug therapy Rats Silybum marianum Skin Diseases - drug therapy transcription factor NF-kappa B
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