Multivalency in the Inhibition of Oxidative Protein Folding by Arsenic(III) Species

The renewed use of arsenicals as chemotherapeutics has rekindled interest in the biochemistry of As(III) species. In this work, simple bis- and tris-arsenical derivatives were synthesized with the aim of exploiting the chelate effect in the inhibition of thiol-disulfide oxidoreductases (here, Quies...

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Veröffentlicht in:	Biochemistry (Easton) 2015-01, Vol.54 (2), p.612-621
Hauptverfasser:	Sapra, Aparna, Ramadan, Danny, Thorpe, Colin
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Arsenic Arsenicals - chemistry Arsenicals - pharmacology Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Humans Models, Molecular Oxidation-Reduction - drug effects Oxidoreductases Acting on Sulfur Group Donors - chemistry Oxidoreductases Acting on Sulfur Group Donors - metabolism Protein Disulfide-Isomerases - chemistry Protein Disulfide-Isomerases - metabolism Protein Folding - drug effects Protozoan Proteins - chemistry Protozoan Proteins - metabolism Trypanosoma brucei brucei - enzymology
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